Cell behaviour of Drosophila fat cadherin mutations in wing development
Cell behaviour of Drosophila fat cadherin mutations in wing development
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DOI：
10.1016/s0925-4773(00)00306-3
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发表时间：
2000-06-01
影响因子：
2.6
通讯作者：
García-Bellido, A
中科院分区：
文献类型：
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作者：
Garoia, F;Guerra, D;García-Bellido, A
我们研究了果蝇想象翼盘发育中脂肪(Fr)突变等位基因的几个细胞行为参数。突变的成像盘在延迟化蛹的幼虫中继续生长，大小可以达到野生型的几倍。然而，它们的生长基本上是异速生长的。纯合子ft细胞在克隆中比其孪生细胞生长得更快，并产生更大的区域，尽管受到正常克隆限制的限制。此外，克隆中的ft细胞倾向于向翅膀近端区域生长。这些行为可能与细胞粘附性和细胞识别失败有关。双突变与其他基因的等位基因组合，例如表皮生长因子受体(DER)途径，改变了ft克隆表型，表明粘附性受细胞间信号的调节。此外，突变的ft细胞在增殖过程中表现出较小的细胞尺寸和异常的角质层分化，这反映了细胞膜和细胞骨架的异常，这不受DER途径的调节。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
We have studied several cell behaviour parameters of mutant alleles of fat (fr) in Drosophila imaginal wing disc development. Mutant imaginal discs continue growing in larvae delayed in pupariation and can reach sizes of several times those of wild-type. Their growth is, however, basically allometric. Homozygous ft cells grow faster than their twin cells in clones and generate larger territories, albeit delimited by normal clonal restrictions. Moreover,ft cells in clones tend to grow towards wing proximal regions. These behaviours can be related with failures in cell adhesiveness and cell recognition. Double mutant combinations with alleles of other genes, e.g. of the Epidermal growth factor receptor (DER) pathway, modify ft clonal phenotypes, indicating that adhesiveness is modulated by intercellular signalling. Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.