PELP1: Structure, biological function and clinical significance.
PELP1: Structure, biological function and clinical significance.
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DOI：
10.1016/j.gene.2016.03.017
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发表时间：
2016-07-01
期刊：
影响因子：
3.5
通讯作者：
Vadlamudi RK
中科院分区：
文献类型：
--
作者：
Sareddy GR;Vadlamudi RK
富含脯氨酸、谷氨酸和亮氨酸的蛋白1(PELP1)是一种支架蛋白，作为多种转录因子和核受体的共同调节因子。值得注意的是，PELP1蛋白具有一个组蛋白结合域，识别组蛋白修饰并与几个染色质修饰复合体相互作用。PELP1是多种激酶的底物，磷酸化调节其在各种复合体中的功能。此外，PELP1在激素信号、细胞周期进程、核糖体生物发生和DNA损伤反应等几个途径中发挥重要作用。PELP1在几种癌症中表达上调，它的失控有助于治疗抵抗，它是乳腺癌生存的预后生物标志物。最近的证据表明，PELP1是许多荷尔蒙癌症的新治疗靶点。本文就PELP1的生物学特性和功能作一综述。
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1.