Frailty and multiple comorbidities in the elderly patient with heart failure: implications for management.
Frailty and multiple comorbidities in the elderly patient with heart failure: implications for management.
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DOI：
10.1007/s10741-011-9258-y
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发表时间：
2012-09
影响因子：
4.6
通讯作者：
Kitzman, Dalane W.
中科院分区：
文献类型：
--
作者：
Murad, Khalil;Kitzman, Dalane W.
老年人心力衰竭（HF）是一个主要的公共卫生问题，其患病率正在上升。尽管引入了新型HF治疗，但在过去20年中，老年人HF的结局没有改变。这可能是由于多种合并症和虚弱的综合影响。大多数老年HF患者身体虚弱，伴有多种合并症。这些合并症，沿着虚弱，导致老年人心力衰竭的不良结局，并提出了独立的管理挑战。需要进行更多的研究，以便：更好地了解虚弱和多种合并症之间的相互作用及其影响HF及其管理的机制;开发包括虚弱和多种合并症的预后工具，并提供更准确的结局预测;在典型老年患者中测试可用的治疗方法;开发和测试直接解决多种合并症和虚弱的不良影响的新型干预措施。
Heart failure (HF) in the elderly is a major public health problem, and its prevalence is rising. Outcomes of HF in the elderly have not changed in the past 2 decades despite the introduction of novel HF therapies. This may be due to the combined impact of multiple comorbidities and frailty. The majority of elderly patients with HF are frail with multiple comorbidities. These comorbidities, along with frailty, contribute to the poor outcome of HF in the elderly and pose independent management challenges. More research is needed to: better understand the interaction between frailty and multiple comorbidities and the mechanisms by which they impact HF and its management; develop prognostic tools that incorporate frailty and multiple comorbidities and provide more accurate prediction of outcomes; test available treatments in typical elderly patients; and develop and test novel interventions that directly address the adverse impact of multiple co-morbidities and frailty.
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DOI：
10.1016/0021-9681(76)90080-1
发表时间：
1976-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
FEINSTEIN, AR;LANDIS, JR
通讯作者：
LANDIS, JR
影响因子：
2.8
作者：
Mockler, Mary;O'Loughlin, Christina;Ledwidge, Mark Thomas
通讯作者：
Ledwidge, Mark Thomas
影响因子：
120.7
作者：
Kitzman, DW;Little, WC;Stewart, KP
通讯作者：
Stewart, KP
DOI：
10.1056/nejmoa1010029
发表时间：
2010-12-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chaudhry SI;Mattera JA;Curtis JP;Spertus JA;Herrin J;Lin Z;Phillips CO;Hodshon BV;Cooper LS;Krumholz HM
通讯作者：
Krumholz HM
影响因子：
4.6
作者：
Jugdutt, Bodh I.
通讯作者：
Jugdutt, Bodh I.