A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab.
A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab.
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DOI：
10.1159/000445285
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发表时间：
2016-01
影响因子：
0.4
通讯作者：
Ishida S
中科院分区：
文献类型：
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作者：
Sakurai Y;Namba K;Mizuuchi K;Nomura T;Ishida S
寻常型银屑病相关的葡萄膜炎通常表现为眼前节炎症，很少有炎症扩展到后节。我们在此报告一例严重的全葡萄膜炎与寻常型银屑病相关，表现为视网膜新生血管，导致玻璃体破裂，并成功地用英夫利昔单抗（IFX）治疗。一位27岁男性寻常型乾癣患者因长期严重葡萄膜炎而转介至本院。他表现出严重的前房炎症，伴有纤维蛋白形成和虹膜后粘连。局部皮质类固醇治疗，这些条件缓解了很短的时间，然而，眼内炎症加剧与视网膜新生血管OS引起的玻璃体水肿。IFX治疗后，眼内炎症和视网膜新生血管的管理得到解决，到目前为止，没有严重的复发已经看到3年的治疗。当我们看到与银屑病相关的严重全葡萄膜炎患者延伸到眼后段时，IFX治疗可能是一个很好的治疗选择。
Uveitis associated with psoriasis vulgaris is usually seen as an anterior segment inflammation, and it is very rare that the inflammation extends to the posterior segment. We herein report a case of severe panuveitis associated with psoriasis vulgaris presenting as retinal neovascularization, leading to vitreous hemorrhages that were successfully treated with infliximab (IFX). A 27-year-old male with psoriasis vulgaris was referred to our hospital due to prolonged severe uveitis OU. He showed a severe anterior chamber inflammation with fibrin formation and total posterior iris synechia OU. With topical corticosteroid treatment, these conditions were relieved for a short time; however, the intraocular inflammation was exacerbated with vitreous hemorrhages caused by retinal neovascularization OS. After the administration of IFX therapy, the intraocular inflammation and retinal neovascularization was resolved, and so far, no severe recurrences have been seen for 3 years with the therapy. When we see patients with severe panuveitis associated with psoriasis extending to the posterior segment, IFX treatment may be a good therapeutic option.