Evaluation of silver-containing activated carbon fiber for wound healing study: In vitro and in vivo
Evaluation of silver-containing activated carbon fiber for wound healing study: In vitro and in vivo
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DOI：
10.1002/jbm.b.32800
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发表时间：
2012-11-01
影响因子：
3.4
通讯作者：
Tseng, Guan-Chin
中科院分区：
文献类型：
--
作者：
Lin, Yu-Hsin;Lin, Jui-Hsiang;Tseng, Guan-Chin
银具有抗菌、抗炎的特性，是多种耐药菌株的广谱抗生素。市售产品Silverlon (R)是一种镀银的三维聚酰胺织物，银浓度高达546毫克/100平方厘米。因此，当暴露于Silverlon (R)处理的细胞培养基中时，成纤维细胞的生长受到影响。我们的研究生产了一种含有不同银浓度的活性炭纤维伤口敷料（与生物医学碳技术合作），以检测抗菌性能，并确定暴露于银浸渍敷料材料时的成纤维细胞活力，与其他市售产品(如海藻酸钙敷料Sorbalgon （R)和银聚酰胺织物敷料Silverlon (R)）相比。与Silverlon (R)相比，浸渍银的活性炭纤维敷料对成纤维细胞的损伤更小，并且在体外表现出相似的抗菌能力。体内分析表明，不同浓度的银浸渍活性炭纤维敷料可促进铜绿假单胞菌感染大鼠伤口的组织重建和愈合。(c) 2012 Wiley期刊有限公司[J]中国生物医学工程学报，2012。
Silver has antiseptic properties, anti-inflammatory properties, and is a broad-spectrum antibiotic for multidrug-resistant strains of bacteria. The commercially available product, Silverlon (R), is a silver-plated three-dimensional polyamide fabric with a high silver concentration of 546 mg/100 cm2. Thus, fibroblast cell growth is affected when exposed to the Silverlon (R) treated cell medium. Our study produced an activated carbon fiber wound dressing that incorporated various silver concentrations (in cooperation of Bio-Medical Carbon Technology) to examine antimicrobial properties and determine fibroblast cell viability upon exposure to the silver impregnated dressing material as compared to other commercially available products such as calcium alginate dressing, Sorbalgon (R), and silver-polyamide fabric dressing, Silverlon (R). The silver impregnated activated carbon fiber dressing induced less damage to fibroblast cells compared to the effect produced by Silverlon (R) and exhibited similar antibacterial abilities in vitro. An in vivo analysis showed that various silver concentrations impregnated activated carbon fiber dressings promoted tissue reconstruction for wound healing in rats with Pseudomonas aeruginosa infected wounds. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.