Smart Radiation Therapy Biomaterials.
Smart Radiation Therapy Biomaterials.
复制标题
DOI：
10.1016/j.ijrobp.2016.10.034
复制
发表时间：
2017-03-01
期刊：
影响因子：
--
通讯作者：
Hesser J
中科院分区：
文献类型：
--
作者：
Ngwa W;Boateng F;Kumar R;Irvine DJ;Formenti S;Ngoma T;Herskind C;Veldwijk MR;Hildenbrand GL;Hausmann M;Wenz F;Hesser J
放射治疗是癌症治疗的重要组成部分，用于治疗超过 50% 的癌症患者。接受图像引导放射治疗或近距离放射治疗的患者通常会将惰性放射治疗（RT）生物材料植入其肿瘤中。这些 RT 生物材料的唯一功能是确保治疗过程中的几何精度。最近的研究提出，惰性生物材料可以升级为“智能”RT 生物材料，旨在实现多种功能。这种智能生物材料包括下一代基准标记、近距离放射治疗垫片和球囊施放器，旨在响应刺激并执行额外的所需功能，例如将治疗增强有效负载直接受控输送到肿瘤子体积中，同时最大限度地减少正常组织毒性。更广泛地说，智能 RT 生物材料可能包括功能化纳米颗粒，可以激活它们以提高放射治疗效果。这项工作回顾了智能放射治疗生物材料的基本原理、这一新兴跨学科研究领域的最新技术、进一步研究和开发的挑战/机遇以及潜在临床应用的范围。涵盖的应用包括使用智能 RT 生物材料以最小的副作用促进癌症治疗、将放疗与免疫疗法或化疗相结合、减少治疗时间或医疗费用以及其他初期应用。
Radiotherapy is a crucial component of cancer care, employed in the treatment of over 50% of cancer patients. Patients undergoing image-guided radiotherapy or brachytherapy routinely have inert radiotherapy (RT) biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to ‘smart’ RT biomaterials, designed to do more than one function. Such smart biomaterials include next generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimulus and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor sub-volume, while minimizing normal tissue toxicities. More broadly, smart RT biomaterials may include functionalized nanoparticles that can be activated to boost radiotherapy efficacy. This work reviews the rationale for smart radiotherapy biomaterials, the state-of-the-art in this emerging cross-disciplinary research area, challenges/opportunities for further research and development, and a purview of potential clinical applications. Applications covered include using smart RT biomaterials for boosting cancer therapy with minimal side effects, combining radiotherapy with immunotherapy or chemotherapy, reducing treatment time or healthcare costs, and other incipient applications.