MicroRNAs in renal cell carcinoma: a systematic review of clinical implications (Review).
MicroRNAs in renal cell carcinoma: a systematic review of clinical implications (Review).
复制标题
DOI：
10.3892/or.2015.3799
复制
发表时间：
2015-04
期刊：
影响因子：
4.2
通讯作者：
Wu B
中科院分区：
文献类型：
--
作者：
Li M;Wang Y;Song Y;Bu R;Yin B;Fei X;Guo Q;Wu B
尽管最近对肾细胞癌（RCC）生物学的理解有了进展，成功的手术治疗和新型靶向治疗的实施，但RCC患者的预后仍然很差。出现时间晚、肿瘤异质性，特别是缺乏早期检测、分类和监测RCC治疗的分子生物标志物是主要障碍。关于microRNAs （miRNAs）在病理生理过程中的功能作用的知识日益增加，可能为确定适合的RCC治疗靶点和诊断/预后生物标志物提供重要联系。本综述的目的是提供mirna在RCC发病机制中的功能的新见解，并强调它们作为诊断和预后标志物以及治疗靶点的潜力。
Despite recent advances in the understanding of the biology of renal cell carcinoma (RCC), successful surgical treatment and implementation of novel-targeted therapies, the prognosis for RCC patients remains poor. Late presentation, tumor heterogeneity and in particular the lack of molecular biomarkers for early detection, classification and the surveillance of RCC treatments are major obstacles. The increasing knowledge regarding the functional role of microRNAs (miRNAs) in pathophysiological processes may provide an important link to the identification of suitable therapeutic targets and diagnostic/prognostic biomarkers for RCC. The aim of this review was to provide new insight into the function of miRNAs in the pathogenesis of RCC and to emphasize their potential as diagnostic and prognostic markers, as well as therapeutic targets.