Three new polyketide-terpenoid hybrids from Penicillium sp.
Three new polyketide-terpenoid hybrids from Penicillium sp.
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DOI：
10.1021/ol7029867
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发表时间：
2008-03-06
期刊：
影响因子：
5.2
通讯作者：
Kusumi, Takenori
中科院分区：
文献类型：
--
作者：
Iida, Motoo;Ooi, Takashi;Kusumi, Takenori
从一株小黄青霉菌中分离得到三种新的杂合聚酮-萜类代谢产物。通过核磁共振波谱分析和X-射线晶体学测定了它们的结构。建议的生物合成途径，包括一个独特的反克莱森迁移的碳酸甲酯相关的三种化合物与berkeleydione和berkeleytrione。
Three novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium minioluteum strain. Their structures were determined by NMR spectroscopic analyses and X-ray crystallography. The proposed biosynthetic pathway including a unique retro-Claisen migration of methyl carbonate correlates the three compounds with berkeleydione and berkeleytrione.