Bio-banking
Bio-banking
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DOI：
10.1017/cbo9780511545566.027
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Saginur, Madelaine
中科院分区：
文献类型：
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作者：
Knoppers, Bartha Maria;Saginur, Madelaine
多年来，癌症诊所的医生一直在储存用于临床测试诊断后留下的生物样本。在2000年之前，没有获得储存或研究的同意。2000年，该诊所改变了政策，开始系统地要求同意使用和储存剩余的生物样本“用于未来的癌症研究”。从那时起，诊所只有在病人同意的情况下才储存样本。当患者不同意时，它会丢弃样本。许多样本捐赠者仍然活着（一些仍然是诊所的病人），而其他人已经死亡。该诊所目前拥有4000多个样本，具有全面的临床数据。两组遗传学家希望使用这些样本进行研究，一组研究某些癌症的遗传基础，另一组研究种族和药物反应的遗传基础，这是一项随机的异质人群研究。
For many years, physicians at a cancer clinic have been storing biological samples left over after being used for diagnosis in clinical testing. Prior to 2000, no consent for storage or research was obtained. In 2000, the clinic changed its policy and began to systematically request consent for the use and storage of leftover biological samples "for future cancer research.'' From that point on, the clinic has been storing samples only when the patient consented. It discards samples when the patient does not consent. Many of the sample donors are still alive (some are still patients at the clinic), while others have died. The clinic now has over 4000 samples, with comprehensive clinical data. Two groups of geneticists would like to use the samples for research, one examining the genetic basis of certain cancers, and the other examining the genetic basis of ethnicity and drug response in a randomized, heterogeneous population study.