Suppression of protein adsorption on a graphene surface by phosphorylcholine functionalization
Suppression of protein adsorption on a graphene surface by phosphorylcholine functionalization
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DOI：
10.7567/1347-4065/ab0b37
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发表时间：
2017-08
影响因子：
1.5
通讯作者：
Y. Taniguchi;T. Miki;Y. Ohno;M. Nagase;Y. Arakawa;Y. Imada;K. Minagawa;M. Yasuzawa
中科院分区：
文献类型：
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作者：
Y. Taniguchi;T. Miki;Y. Ohno;M. Nagase;Y. Arakawa;Y. Imada;K. Minagawa;M. Yasuzawa
在这项研究中，我们研究了磷酸胆碱（ChoP）修饰的外延石墨烯膜为基础的设备，用于抑制非特异性蛋白质吸附到石墨烯表面。合成了ChoP-芘衍生物，并利用π-π堆积效应将其固定在外延石墨烯上。ChoP修饰的石墨烯器件抑制了蛋白质吸附引起的转移曲线的偏移，并且这种效应与蛋白质的电荷和类型无关。此外，由于石墨烯表面π电子的强相互作用，超纯水处理15 min后，抑制效果稳定。因此，我们的研究结果表明，使用芘和石墨烯膜的牢固键合，用划时代的ChoP衍生物实现了对蛋白质吸附的稳定阻断。
In this study, we examined phosphorylcholine (ChoP)-modified epitaxial graphene film based devices for the suppression of non-specific protein adsorptions onto a graphene surface. ChoP-pyrene derivatives were synthesized and immobilized on epitaxial graphene by the π–π stacking effect. The shifts in the transfer curve by protein adsorption were suppressed for the ChoP-modified graphene device, and this effect was independent of the charge and type of protein. In addition, the suppression effect was stable after 15 min of treatment with ultra-pure water owing to strong interactions of π electrons on the graphene surface. Consequently, our results indicate a stable blocking for protein adsorptions is achieved with an epochal ChoP derivative using robust bonding of a pyrene and a graphene film.