mei-W68 in Drosophila melanogaster encodes a Spo11 homolog:: evidence that the mechanism for initiating meiotic recombination is conserved
mei-W68 in Drosophila melanogaster encodes a Spo11 homolog:: evidence that the mechanism for initiating meiotic recombination is conserved
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DOI：
10.1101/gad.12.18.2932
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发表时间：
1998-09-15
影响因子：
10.5
通讯作者：
Hayashi-Hagihara, A
中科院分区：
文献类型：
--
作者：
McKim, KS;Hayashi-Hagihara, A
减数分裂重组需要几种基因产物在酿酒酵母和黑腹果蝇中的作用。黑腹盘藻的遗传学研究表明，mei-W68基因是所有减数分裂基因转换和交换所必需的。我们用一种新的遗传作图方法克隆了梅-W68，这种作图方法利用P元件促进插入点处的互换。这导致了MEI-W68的高分辨率映射到
Meiotic recombination requires the action of several gene products in both Saccharomyces cerevisiae and Drosophila melanogaster. Genetic studies in D. melanogaster have shown that the mei-W68 gene is required for all meiotic gene conversion and crossing-over. We cloned mei-W68 using a new genetic mapping method in which P elements are used to promote crossing-over at their insertion sites. This resulted in the high-resolution mapping of mei-W68 to a