Source distribution of neuromagnetic slow waves and MEG-delta activity in schizophrenic patients
Source distribution of neuromagnetic slow waves and MEG-delta activity in schizophrenic patients
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DOI：
10.1016/s0006-3223(01)01122-2
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发表时间：
2001-07-15
影响因子：
10.6
通讯作者：
Elbert, T
中科院分区：
文献类型：
--
作者：
Fehr, T;Kissler, J;Elbert, T
背景：精神分裂症患者在脑电图δ和θ频率范围内比对照组表现出更多的活动。本研究采用磁源成像（MSI）技术，探讨精神分裂症患者脑磁图（MEG）中的这一现象及其来源的分布，以及症状特征与脑低频活动来源之间的关系。方法：对28例精神分裂症患者和20例健康对照者在静息状态下进行全脑MEG记录。采用单移动偶极子模型对磁慢波的发生源进行了定位。分布式或多个三角洲和θ源被捕获的最小范数estimation.Results：这两个本地化程序显示慢波活动在精神分裂症患者与对照组相比，要增强。局灶性慢波活动在额颞和后部区域的组间差异最大。慢波活动与症状特征，积极的症状与额叶三角洲和θ activity.Conclusions：结果表明，在精神分裂症患者的低频带活动超过了控制受试者在不同领域的活动，这可能与精神病理学特征的神经磁慢波的焦点聚集。(C)2001生物精神病学学会。
Background: Schizophrenic patients exhibit more activity in the electroencephalographic delta and theta frequency range than do control subjects. Using magnetic source imaging (MSI) our study aimed to explore this phenomenon in the magnetoencephalogram (MEG), the distribution of its sources, and associations between symptom profiles and sources of low-frequency activity in the brain.Methods: Whole-head MEG recordings were obtained from 28 schizophrenic patients and 20 healthy control subjects during a resting condition. The generators of the focal magnetic slow waves were located employing a single moving dipole model. Distributed or multiple delta and theta sources were captured by the minimum norm estimate.Results: Both localization procedures showed slow wave activity to be enhanced in schizophrenic patients compared with control subjects. Focal slow wave activity differed most between groups in frontotemporal and in posterior regions. Slow wave activity was associated with symptom characteristics in that positive symptoms varied with frontal delta and theta activity.Conclusions: Results indicate that activity in low-frequency bands in schizophrenic patients exceeds the activity of control subjects in distinct areas, and that this focal clustering of neuromagnetic slow waves may be related to psychopathologic characteristics. (C) 2001 Society of Biological Psychiatry.