A common polymorphism is associated with body mass index in Uyghur population.
A common polymorphism is associated with body mass index in Uyghur population.
复制标题
维吾尔族人群中常见的多态性与体重指数相关。
DOI：
10.1016/j.diabres.2008.03.022
复制
发表时间：
2008-08-01
影响因子：
5.1
通讯作者：
Wang, Xiao-feng
中科院分区：
文献类型：
--
作者：
Zhang, Jun;Lin, Rong;Wang, Xiao-feng
本研究的目的是在维吾尔族人群中观察INSIG 2基因附近的一个常见遗传变异（rs7655505）与体重指数（BMI）相关肥胖的相关性。我们观察到rs7566605多态性与维吾尔族BMI相关肥胖显著相关，优势模型（CC+GC vs GG）下的比值比为1.47（95%CI 1.11-1.95，P=0.006）。rs7566605 CC+GC基因型的平均BMI比GG基因型高0.59kg/m2（P=0.024）。
We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.