Effective connectivity within the ventromedial prefrontal cortex-hippocampus-amygdala network during the elaboration of emotional autobiographical memories
Effective connectivity within the ventromedial prefrontal cortex-hippocampus-amygdala network during the elaboration of emotional autobiographical memories
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DOI：
10.1016/j.neuroimage.2019.01.042
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发表时间：
2019-04-01
期刊：
影响因子：
5.7
通讯作者：
Ando, Hiroshi
中科院分区：
文献类型：
--
作者：
Nawa, Norberto Eiji;Ando, Hiroshi
自传体记忆（AM）经常被事件中经历的情绪或进一步评价后产生的情绪所影响。然而，记忆中的情感成分如何影响AM回忆过程中招募的全脑网络仍然在很大程度上未知。在这里，我们研究了有效的连接过程中制定的AM-当检索到的情节细节整合，形成一个生动的结构-在网络组成的腹内侧前额叶皮层（vmPFC），海马和杏仁核，三个关键区域与记忆和情感过程。当志愿者回忆不同类型的效价和情绪强度的个人事件时，功能性MRI数据被收集。使用动态因果模型，我们的特点的三元网络内的连接，并检查它们是如何调制的事件中经历的情绪强度，以及在回忆相关的记忆时引起的影响的效价。结果初步表明，在记忆加工过程中存在一个有效的连接VMPFC海马。此外，当参与者重温高度情绪化的事件或引发更强积极影响的事件时，连接的强度会增加。这些结果表明，vmPFC驱动海马活动在记忆加工，并发挥了关键作用，在塑造情感反应，从AM发出。
Autobiographical memories (AMs) are often colored by emotions experienced during an event or those arising following further appraisals. However, how affective components of memories affect the brain-wide network recruited during the recollection of AMs remains largely unknown. Here, we examined effective connectivity during the elaboration of AMs - when retrieved episodic details are integrated to form a vivid construct - in the network composed by ventromedial prefrontal cortex (vmPFC), hippocampus and amygdala, three key regions associated with memory and affective processes. Functional MRI data was collected while volunteers recollected personal events of different types of valence and emotional intensity. Using dynamic causal modeling, we characterized the connections within the triadic network, and examined how they were modulated by the emotional intensity experienced during an event, and the valence of the affect evoked when recollecting the associated memory. Results primarily indicated the existence of a vmPFC to hippocampus effective connectivity during memory elaboration. Furthermore, the strength of the connectivity increased when participants relived memories of highly emotionally arousing events or that elicited stronger positive affect. These results indicate that the vmPFC drives hippocampal activity during memory elaboration, and plays a critical role in shaping affective responses that emanate from AMs.