Cardiomyocyte DNA synthesis and binucleation during murine development.
Cardiomyocyte DNA synthesis and binucleation during murine development.
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DOI：
10.1152/ajpheart.1996.271.5.h2183
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发表时间：
1996-11
期刊：
影响因子：
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通讯作者：
M. Soonpaa;KYUNG KEUN Kim;L. Pajak;M. Franklin;L. Field
中科院分区：
文献类型：
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作者：
M. Soonpaa;KYUNG KEUN Kim;L. Pajak;M. Franklin;L. Field
在小鼠发育过程中测定心肌细胞DNA合成和双核指数。心肌细胞DNA合成发生在两个时间上不同的阶段。第一阶段发生在胎儿期，仅与心肌细胞增殖相关。第二阶段发生在新生儿早期，与双核。总的来说，这些结果表明，心肌细胞复制停止在晚期胎儿的生活。北方和蛋白质印迹分析确定了几个候选基因，在心肌细胞生长的重复和双核阶段差异表达。
Cardiomyocyte DNA synthesis and binucleation indexes were determined during murine development. Cardiomyocyte DNA synthesis occurred in two temporally distinct phases. The first phase occurred during fetal life and was associated exclusively with cardiomyocyte proliferation. The second phase occurred during early neonatal life and was associated with binucleation. Collectively, these results suggest that cardiomyocyte reduplication ceases during late fetal life. Northern and Western blot analyses identified several candidate genes that were differentially expressed during the reduplicative and binucleation phases of cardiomyocyte growth.