A periodic network of neurochemical modules in the inferior colliculus
A periodic network of neurochemical modules in the inferior colliculus
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DOI：
10.1016/s0378-5955(03)00340-x
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发表时间：
2004-02-01
期刊：
影响因子：
2.8
通讯作者：
Winer, JA
中科院分区：
文献类型：
--
作者：
Chernock, ML;Larue, DT;Winer, JA
在大鼠下丘壳核中发现一种新的结构。具有周期性分布的化学特异性模块填充约一半的第2层外部皮层和背侧皮层。模块包含集群的小谷氨酸脱羧酶阳性神经元和大的终扣在较高的密度比其他下丘亚部。该模块也存在于组织染色的小清蛋白，细胞色素氧化酶，烟酰胺腺嘌呤二核苷酸磷酸-心肌黄酶，乙酰胆碱酯酶。从下丘外侧皮质的尾端到其喙极，有6 ~ 7个左右对称的模块。模块是从类似于800至2200针长，并有5000和40000 μ m（2）之间的区域。模块与免疫阴性区域交替。在大鼠的近交系和远交系以及雄性和雌性中发现了类似的模块。它们在小鼠、松鼠、猫、蝙蝠、猕猴和仓鸮中不存在。模块对甘氨酸、钙结合蛋白、血清素和胆碱乙酰转移酶呈免疫阴性。听觉皮层和同侧和对侧下丘投射到外部皮层。来自背柱核和三叉神经脊束核的躯体感觉影响是对外部皮层的主要上行感觉输入;到第2层的上行听觉输入是稀疏的。如果免疫阳性模块神经元接受这种输入，外部皮层可以通过其内在和外在的投射参与空间定向和躯体运动控制。(C)2003 Elsevier B. V.保留所有权利。
A new organization has been found in shell nuclei of rat inferior colliculus. Chemically specific modules with a periodic distribution fill about half of layer 2 of external cortex and dorsal cortex. Modules contain clusters of small glutamic acid decarboxylase-positive neurons and large boutons at higher density than in other inferior colliculus subdivisions. The modules are also present in tissue stained for parvalbumin, cytochrome oxidase, nicotinamide adenine dinucleotide phosphate-diaphorase, and acetylcholinesterase. Six to seven bilaterally symmetrical modules extend from the caudal extremity of the external cortex of the inferior colliculus to its rostral pole. Modules are from similar to800 to 2200 pin long and have areas between 5000 and 40 000 mum(2). Modules alternate with immunonegative regions. Similar modules are found in inbred and outbred strains of rat, and in both males and females. They are absent in mouse, squirrel, cat, bat, macaque monkey, and barn owl. Modules are immunonegative for glycine, calbindin, serotonin, and choline acetyltransferase. The auditory cortex and ipsi- and contralateral inferior colliculi project to the external cortex. Somatic sensory influences from the dorsal column nuclei and spinal trigeminal nucleus are the primary ascending sensory input to the external cortex; ascending auditory input to layer 2 is sparse. If the immunopositive modular neurons receive this input, the external cortex could participate in spatial orientation and somatic motor control through its intrinsic and extrinsic projections. (C) 2003 Elsevier B.V. All rights reserved.