Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease
Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease
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DOI：
10.1016/j.visres.2004.06.006
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发表时间：
2004-10-01
期刊：
影响因子：
1.8
通讯作者：
Foroud, TM
中科院分区：
文献类型：
--
作者：
Blekher, TM;Yee, RD;Foroud, TM
我们比较了亨廷顿病（HD）早期个体与症状前HD基因携带者（PSGC）和非基因携带者（NGC）的眼部控制。视力测试范式包括传统的测试和一个新的实验程序来评估视觉扫描。传统的测试引起扫视，追求和视动性眼球震颤（OKN）。HD患者表现出明显的自主扫视（反扫视和记忆引导的扫视）启动延迟，正确的自主扫视次数减少，扫视速度降低，OKN增益降低。我们还研究了视觉扫描，而参与者完成了韦氏成人智力调查修订版（WAIS-R）的数字符号分量表。HD参与者表现出异常的凝视策略，这可能与注意力和/或计划缺陷有关。PSGC和NGC组之间的差异仅在两个方面观察到：PSGC的记忆引导扫视次数减少，意志扫视的启动延迟。我们的研究结果表明，眼科措施是一个敏感的生物标志物在早期阶段的HD和证明，更传统的眼科测试与视觉扫描测试相结合是有用的视觉性能的评价。(C)2004爱思唯尔有限公司保留所有权利。
We compared oculomotor control among individuals in the early stages of Huntington's disease (HD), with that of individuals who are presymptomatic HD gene carriers (PSGC) and nongene carriers (NGC). The oculomotor testing paradigm included both traditional tests and a novel experimental procedure to assess visual scanning. Traditional tests elicited saccades, pursuit and optokinetic nystagmus (OKN). HD patients demonstrated marked delay in the initiation of volitional saccades (anti-saccade and memory-guided saccades), a reduced number of correct volitional saccades, reduced velocity of saccades, and a decreased OKN gain. We also studied visual scanning while the participants completed the Digit Symbol Subscale of the Wechsler Adult Intelligence Survey-Revised (WAIS-R). The HD participants demonstrated an abnormal gaze strategy, which may be associated with attention and/or planning deficits.Differences between the PSGC and NGC groups were only observed for two measures: PSGC had a decreased number of memory-guided saccades and a subtle delay in the initiation of volitional saccades. Our results suggest that oculomotor measures are a sensitive biomarker in the early stage of HD and demonstrate that the combination of more traditional oculomotor tests with visual scanning tests is useful in the evaluation of visual performance. (C) 2004 Elsevier Ltd. All rights reserved.