Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study.
Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study.
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DOI：
10.1111/j.1532-5415.2010.03233.x
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发表时间：
2011-01
影响因子：
6.3
通讯作者：
Kotchen JM
中科院分区：
文献类型：
--
作者：
Goveas JS;Espeland MA;Woods NF;Wassertheil-Smoller S;Kotchen JM
研究绝经后妇女中显著抑郁症状的存在是否会增加随后轻度认知障碍和痴呆的风险。前瞻性队列研究。40个妇女健康倡议（WHI）临床中心中的39个参加了激素治疗的随机临床试验。6376例基线时年龄为65-79岁的无认知障碍的绝经后女性。抑郁症的评估使用8项Burnam算法，每年随访一次，平均随访时间为5.4年。根据广泛的神经精神检查，由中央裁定委员会对轻度认知障碍和可能痴呆的存在进行分类。在该样本中，8.0%的绝经后妇女报告了Burnam算法上高于0.06临界点的抑郁症状。基线时抑郁障碍与轻度认知功能障碍的风险增加相关（风险比，1.98; 95%置信区间，1.33-2.94），可能痴呆（风险比，2.03; 95%置信区间，1.15-3.60），以及轻度认知障碍或可能的痴呆（风险比，1.92; 95%置信区间，1.35-2.73），在控制了社会人口特征、生活方式和血管危险因素、心血管和脑血管疾病、抗抑郁药使用以及当前和过去的激素治疗状态后。这些关系不受分配到激素治疗和基线认知功能。目前，非抑郁症妇女谁认可的抑郁症的远程历史有更高的风险发展为痴呆症。在65岁及以上的女性中，临床上显著的抑郁症状与轻度认知障碍和可能的痴呆的发病率增加独立相关。
To examine whether the presence of significant depressive symptoms among postmenopausal women increases the risk of subsequent mild cognitive impairment and dementia. Prospective cohort study. Thirty nine of the 40 Women’s Health Initiative (WHI) clinical centers that participated in a randomized clinical trial of hormone therapy. 6376 postmenopausal women without cognitive impairment aged 65–79 years at baseline. Depressive disorders were assessed using an 8-item Burnam algorithm and followed annually for a mean period of 5.4 years. The presence of Mild Cognitive Impairment and Probable Dementia was classified by a central adjudication committee based on an extensive neuropsychiatric examination. Depressive symptoms above 0.06 cutpoint on Burnam algorithm were reported by 8.0% of postmenopausal women in this sample. Depressive disorder at baseline was associated with an increased risk of incident mild cognitive impairment (hazard ratio, 1.98; 95% confidence interval, 1.33–2.94), probable dementia (hazard ratio, 2.03; 95% confidence interval, 1.15–3.60), and either mild cognitive impairment or probable dementia (hazard ratio, 1.92; 95% confidence interval, 1.35–2.73), after controlling for sociodemographic characteristics, lifestyle and vascular risk factors, cardiovascular and cerebrovascular disease, antidepressant use and current and past hormone therapy status. These relationships were unaffected by assignment to hormone therapy and baseline cognitive function. Currently non-depressed women who endorsed a remote history of depression had a higher risk of developing dementia. Clinically significant depressive symptoms among women 65 years and older are independently associated with an increased incidence of mild cognitive impairment and probable dementia.
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影响因子：
2.1
作者：
Butters, Meryl A.;Klunk, William E.;Meltzer, Carolyn C.
通讯作者：
Meltzer, Carolyn C.
影响因子：
9.9
作者：
Devanand, D. P.;Pradhaban, G.;de Leon, M. J.
通讯作者：
de Leon, M. J.
DOI：
10.1046/j.1532-5415.2003.51352.x
发表时间：
2003-08-01
影响因子：
6.3
作者：
Fuhrer, R;Dufouil, C;Dartigues, JF
通讯作者：
Dartigues, JF
影响因子：
--
作者：
Irie, Fumiko;Masaki, Kamal H.;White, Lon R.
通讯作者：
White, Lon R.
影响因子：
7.2
作者：
Becker, James T.;Chang, Yue-Fang;Reynolds, Charles F.
通讯作者：
Reynolds, Charles F.