Rapid publication - Gene-environment interactions in the development of combined type ADHD: Evidence for a synapse-based model
Rapid publication - Gene-environment interactions in the development of combined type ADHD: Evidence for a synapse-based model
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DOI：
10.1002/ajmg.b.30640
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发表时间：
2007-12-05
影响因子：
2.8
通讯作者：
Neuman, Rosalind J.
中科院分区：
文献类型：
--
作者：
Todd, Richard D.;Neuman, Rosalind J.
为了确定产前吸烟暴露和儿童基因型在注意缺陷/多动障碍（ADHD）发展中的相互作用机制，我们使用多元逻辑回归测试了CHRNA4基因多态性与产前吸烟暴露对ADHD亚型风险的相互作用。外显子5多态性。证明孕妇孕期吸烟史与严重合并型ADHD风险增加有显著的相互作用（人群定义的严重合并型OR=3.0, 95% Cl 1.1-8.4， DSM-IV定义的合并亚型ADHD OR=3.9 95% CI 1.2-13.1）。这种相互作用增加了先前报道的DRD4和DAT1基因与产前吸烟暴露的相互作用的影响。考虑到这三种基因在前额叶皮层多巴胺能突触的已知功能和已知表达区域，研究结果与基于突触的ADHD发展模型是一致的。这些发现的亚型特异性支持了ADHD是由一组不同的疾病组成的概念。(c) 2007 Wiley-Liss, Inc。
To determine the mechanism of interaction of prenatal smoking exposure and child genotype in the development of attention deficit/hyperactivity disorder (ADHD), polymorphisms in the CHRNA4 gene were tested for interactions with prenatal smoking exposure on risk for ADHD subtypes using multiple logistic regression. An exon 5 polymorphism. demonstrated a significant interaction with history of maternal smoking during pregnancy for increasing risk for severe combined type ADHD (OR=3.0, 95% Cl 1.1-8.4 for population-defined severe combined type, OR=3.9 95% CI 1.2-13.1 for DSM-IV defined combined subtype ADHD). This interaction increased the effects of previously reported interactions for the DRD4 and DAT1 genes with prenatal smoking exposure. Given the known functions and the known areas of expression of these three genes at the dopaminergic synapse in the pre-frontal cortex, the results are compatible with a synapse-based model of the development of this form of ADHD. The subtype specificity of these findings supports the concept that ADHD is composed of a group of distinct disorders. (c) 2007 Wiley-Liss, Inc.