Possible oncogenesis of mucinous cystic tumors of the pancreas lacking ovarian-like stroma
Possible oncogenesis of mucinous cystic tumors of the pancreas lacking ovarian-like stroma
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DOI：
10.1159/000065090
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发表时间：
2002-01-01
期刊：
影响因子：
3.6
通讯作者：
Yanagisawa, A
中科院分区：
文献类型：
--
作者：
Shimizu, Y;Yasui, K;Yanagisawa, A
背景/目的：回顾胰腺粘液囊性肿瘤（mct）的临床病理特征和术后结果。我们比较具有卵巢样基质的MCT （MCTs-OLS+, n = 6）和缺乏卵巢样基质的MCT (MCTs-OLS-, n = 4)，以阐明没有OLS的MCT的肿瘤发生机制。患者与方法：对10例MCT患者进行研究。结果：6例MCTs-OLS+均为女性，位于胰腺体和尾部。平均肿瘤大小为6.5 cm（范围2-11 cm）。大多数MCTs-OLS+(5/6)为多房性，在囊壁和中隔上表现出MCTs-OLS+的特征。病理分类为腺瘤4例，非侵袭性腺癌2例。6例患者均存活，术后6 ~ 124个月无肿瘤复发。4例MCTs-OLS-中，男2例，女2例；MCTs-OLS-位于胰腺尾部。肿瘤平均大小为6.9 cm（范围4 ~ 8.4 cm）。4例患者均为胰腺实质或胰腺外组织浸润性癌，囊肿壁上皮病理分类均为腺癌。这些结果也与常见的胰腺浸润性导管癌并假性囊肿继发保留囊肿相一致。所有患者均死亡（术后15、27、31、80个月）。OLS是否对胰腺mct有特异性，需要在未来的研究中进一步明确。结论：我们的研究结果对MCTs-OLS的发生机制提出了三种假设：(1)在浸润性癌发展过程中OLS消失的MCTs；(2)胰腺导管内乳头状粘液瘤衍生的晚期癌症；(3)胰腺浸润性导管癌伴继发性囊肿。版权所有(C) 2002 S. Karger AG， Basel和IAP。
Background/Aims: Clinicopathological features and postoperative results from mucinous cystic tumors of the pancreas (MCTs) were reviewed. MCTs with ovarian-like stroma (MCTs-OLS+; n = 6) and those lacking ovarian-like stroma (MCTs-OLS-; n = 4) were compared to elucidate the oncogenesis of MCT without OLS. Patients and Methods: Ten patients with MCT were studied. Results: The 6 MCTs-OLS+ cases occurred in females and were located in the body and tail of the pancreas. The mean tumor size was 6.5 cm (range 2-11 cm). The majority (5/6) of MCTs-OLS+ were multilocular and exhibited tiny loculi on the cyst wall and septum characteristic of MCTs-OLS+. Pathological classifications were adenoma in 4 patients and noninvasive adenocarcinoma in 2 patients. All 6 patients were alive without tumor recurrence 6-124 months after tumor resection. Of the 4 MCTs-OLS- cases, 2 were males and 2 females; MCTs-OLS- were located in the tail of the pancreas. The mean tumor size was 6.9 cm (range 4-8.4 cm). Invasive cancer in the pancreatic parenchyma or extrapancreatic tissue was recognized in all 4 patients, and the pathological classification of epithelia of the cyst wall were adenocarcinomas. These findings were also compatible with common invasive ductal carcinomas of the pancreas with secondary retention cyst on pseudocyst. All patients died of the disease (15, 27, 31 and 80 months after resection, respectively). Whether or not OLS is specific for MCTs of the pancreas should be clarified in future studies. Conclusion: The results of our study led to three hypotheses regarding the oncogenesis of MCTs-OLS-: (1) MCTs in which OLS disappears during the development of invasive carcinoma; (2) advanced cancer derived from intraductal papillary mucinous tumor of the pancreas, and (3) invasive ductal carcinoma of the pancreas with secondary cyst. Copyright (C) 2002 S. Karger AG, Basel and IAP.