Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.
Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.
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DOI：
10.1002/jcb.25164
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发表时间：
2015-10
影响因子：
4
通讯作者：
Shaikh NN
中科院分区：
文献类型：
--
作者：
Rogers MB;Shah TA;Shaikh NN
骨形态发生蛋白2（BMP 2，HGNC：1069，GeneID：650）基因表达的浓度、位置和时间必须精确调控。异常的BMP 2水平会导致先天性异常和疾病，这些疾病涉及分化为肌肉、脂肪、软骨和骨骼的间充质细胞。影响BMP 2合成的分子和条件是多种多样的。可以理解，复杂的机制控制Bmp2基因表达。这篇评论包括一个汇编的代理商和条件，可以诱导BMP2。目前已知的反式调节因子和顺式调节元件，调节Bmp2的表达进行了总结和讨论。本文受版权保护。版权所有
The concentration, location, and timing of bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) gene expression must be precisely regulated. Abnormal BMP2 levels cause congenital anomalies and diseases involving the mesenchymal cells that differentiate into muscle, fat, cartilage, and bone. The molecules and conditions that influence BMP2 synthesis are diverse. Understandably, complex mechanisms control Bmp2 gene expression. This review includes a compilation of agents and conditions that can induce Bmp2. The currently known trans-regulatory factors and cis-regulatory elements that modulate Bmp2 expression are summarized and discussed. This article is protected by copyright. All rights reserved