Ex vivo simulation of in vivo strain distributions in the equine metacarpus.
Ex vivo simulation of in vivo strain distributions in the equine metacarpus.
复制标题
马掌骨体内应变分布的离体模拟。
DOI：
10.1111/j.2042-3306.1998.tb04498.x
复制
发表时间：
1998
影响因子：
2.2
通讯作者：
Willits,NH
中科院分区：
文献类型：
--
作者：
Les,CM;Stover,SM;Taylor,KT;Keyak,JH;Willits,NH
本研究的目的是检查马掌骨的几种简单体内加载条件，并评估其再现先前在步行和小跑时体内证实的中段骨干骨表面应变分布的能力。对6匹1-5岁纯种马的掌骨远端腕骨制备物施加分布式轴向压缩载荷和9个不同的轴向压缩点载荷（-7.5 kN和-1-5 kN）。使用均方根误差（RMSE）方案将所得背侧、内侧、手掌和外侧中段骨干骨表面轴向和剪切应变与先前在体内表面应变分布中确定的结果进行比较。采用混合模型方差分析评估载荷条件和载荷大小对RMSE的影响。在体内应变分布与体内应变分布的拟合中，载荷条件之间以及载荷大小之间存在显著差异。在体内，行走时的骨表面应变分布可以通过分布轴向压缩载荷或位于矢状中线内侧0.5 cm处的点载荷很好地近似于体内，在小跑的活体骨骼-骨干骨表面应变分布可以很好地近似为施加到相同位置的−15 kN载荷。这些简化的加载条件可用于设计活力学试验研究的生物相关加载方案，以及开发有限元分析的边界条件。因此，这些加载条件可被视为在骨折固定器械开发的初始设计和试验阶段复制活加载条件的工具。以及掌骨结构的理论力学分析。
The objective of this study was to examine several simpleex vivoloading conditions for the equine metacarpus, and to evaluate their ability to reproduce the mid‐diaphyseal bone surface strain distributions previously reportedin vivoat the walk and trot. Distributed axial compressive loads, and 9 different axial compressive point loads at −7.5 kN and −15 kN were applied to metacarpal‐distal carpal bone preparations from 6 Thoroughbred horses, aged 1–5 years. The resulting dorsal, medial, palmar, and lateral mid‐diaphyseal bone surface axial and shear strains were compared with previously reportedin vivosurface strain distributions using a root mean square error (RMSE) protocol. The effects of loading condition and load magnitude on RMSE were assessed with a mixed‐model analysis of variance. There were significant differences between loading conditions, and, in most cases, between load magnitudes, in the fit of theex vivoto thein vivostrain distributions.In vivomid‐diaphyseal bone surface strain distributions at the walk can be well approximatedex vivoby a distributed axial compressive load, or by a point load positioned 0.5 cm mediad to the sagittal midline, at −7.5 kN loads.In vivomid‐diaphyseal bone surface strain distributions at the trot can be well approximated by the −15 kN loads applied to the same locations. These simplified loading conditions can be used in designing biologically relevant loading protocols forex vivomechanical testing studies, as well as in developing boundary conditions for finite element analysis.As such, these loading conditions may be considered as tools to be used as a means of replicatingin vivoloading conditions during the intial design and testing stages in the development of fracture fixation devices, as well as in the theoretical mechanical analysis of the metacarpal structure.