Direct synthesis of 2,5-disubstituted oxazoles through an iodine-catalyzed decarboxylative domino reaction.
Direct synthesis of 2,5-disubstituted oxazoles through an iodine-catalyzed decarboxylative domino reaction.
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DOI：
10.1021/jo400753n
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
W. Xu;Ulrich Kloeckner;B. Nachtsheim
中科院分区：
文献类型：
--
作者：
W. Xu;Ulrich Kloeckner;B. Nachtsheim
报道了碘催化合成高取代恶唑的新方法。以容易获得的芳基甲基酮、β-酮酯或苯乙烯为原料，与α-氨基酸作为含胺偶联配体，通过脱羧多米诺反应得到相应的2-烷基-5-芳基取代恶唑，产率高达80%。
An efficient iodine-catalyzed synthesis of highly substituted oxazoles is presented. Starting from readily available aryl methyl ketones, β-keto esters, or styrenes, in combination with α-amino acids as amine-containing coupling partners, the corresponding 2-alkyl-5-aryl- substituted oxazoles were obtained in up to 80% yield via a decarboxylative domino reaction.