Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
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跨线粒体线粒体小鼠Δ和线粒体DNA突变小鼠（但老年小鼠除外）具有相同的肌肉骨骼疾病谱。
DOI：
10.1016/j.bbrc.2014.12.009
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发表时间：
2015
影响因子：
3.1
通讯作者：
Hayashi J-I
中科院分区：
文献类型：
--
作者：
Mito T;Ishizaki H;Suzuki M;Morishima H;Ota A;Ishikawa K;Nakada K;Maeno A;Shiroishi T;Hayashi J-I
与衰老和线粒体疾病相关的表型谱有时似乎相互重叠。我们使用衰老小鼠和线粒体疾病小鼠模型（mtDNA缺失的传线粒体mito-miceΔ）来研究mtDNA突变小鼠中观察到的早衰表型是否与衰老或线粒体疾病相关。在这里，我们提供了令人信服的证据，证明所有被检查的小鼠都有骨质疏松症和肌肉萎缩的肌肉骨骼疾病，这与老年人普遍观察到的表型相对应。然而，对肌肉骨骼疾病的精确研究表明，mtDNA突变小鼠的骨质疏松和肌肉萎缩表型谱与mito-miceΔ非常接近，但与老年小鼠不同。因此，mtDNA突变小鼠和mito-miceΔ，而不是老年小鼠，共享肌肉骨骼疾病的频谱。
The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceΔ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mutator mice are associated with aging or mitochondrial diseases. Here, we provide convincing evidence that all the mice examined had musculoskeletal disorders of osteoporosis and muscle atrophy, which correspond to phenotypes prevalently observed in the elderly. However, precise investigation of musculoskeletal disorders revealed that the spectra of osteoporosis and muscle atrophy phenotypes in mtDNA mutator mice were very close to those in mito-miceΔ, but different from those of aged mice. Therefore, mtDNA mutator mice and mito-miceΔ, but not aged mice, share the spectra of musculoskeletal disorders.