Microsatellite diversity in Andhra Pradesh, India: Genetic stratification versus social stratification
Microsatellite diversity in Andhra Pradesh, India: Genetic stratification versus social stratification
复制标题
DOI：
10.1353/hub.2006.0018
复制
发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Singh, Lalji
中科院分区：
文献类型：
--
作者：
Reddy, B. Mohan;Naidu, V. M.;Singh, Lalji
对来自南部安得拉邦27个种群的948个个体的DNA样本进行了9个AmpFISTR Profiler Plus位点的分析。参考社会经济和地理关系，研究了这些人群内部和之间基因组多样性的性质和程度。结果表明，这些群体的平均杂合度一致较高（> .80），等位基因分布模式在不同群体中相似。基因分化系数值、AMOVA和结构分析结果表明，这些群体具有高度的同质性。使用D-A或F-ST距离构建的邻居连接树表明，基于民族历史或地理关系的人口集群没有可理解的模式。所有这些观察结果表明，要么这些种群有一个共同的近期起源，要么这些种群之间广泛的基因流动抹去了原始的遗传差异。鉴于严格的内婚制，后一种解释只有在存在未经授权或未被承认的基因流跨越社会界限的情况下才能成立。然而，基于Harpending和Ward（1982）模型的平均杂合度与离质心距离（R-ii）的回归图，以及安得拉邦内不同等级群体之间计算的遗传距离倾向于支持这一猜想。总体而言，结果表明缺乏显著程度的遗传分层，这与安得拉邦的社会分层一致。此外，基于与其他印度和大陆人口的比较数据的邻居结合树显示，所有安得拉邦人口都是一个单一而紧凑的集群，与其他人口明显分开。
DNA samples of 948 individuals belonging to 27 populations from southern Andhra Pradesh were analyzed for nine AmpFISTR Profiler Plus loci. The nature and extent of genomic diversity within and between these populations have been examined with reference to socioeconomic and geographic affiliations. The results suggest that the average heterozygosity is uniformly high in these populations (> 0.80) and that the patterns of allele distributions are similar across the populations. The value of the coefficient of gene differentiation and the AMOVA and structure analysis results suggest that these populations are highly homogeneous. The neighbor-joining tree constructed using either D-A or F-ST distances suggests no intelligible pattern of population clusters based on ethnohistoric or geographic affiliations. All these observations suggest either a common recent origin of these populations or extensive gene flow across the populations that erased the original genetic differences. Given strict endogamy, the latter explanation can hold only if there has been unauthorized or unrecognized gene flow transecting the social boundaries. Nevertheless, the regression plot of average heterozygosity versus distance from the centroid (R-ii), based on Harpending and Ward's (1982) model, and the genetic distances computed between different hierarchical groups within Andhra Pradesh tend to support this conjecture. Overall, the results suggest lack of a significant degree of genetic stratification that is consistent with social stratification in Andhra Pradesh. Furthermore, the neighbor-joining tree based on comparative data from other Indian and continental populations brings out a single and compact cluster of all the Andhra populations that is clearly separated from the rest.