Ligand-induced changes in T box antiterminator RNA stability.
Ligand-induced changes in T box antiterminator RNA stability.
复制标题
配体诱导的 T 盒抗终止子 RNA 稳定性变化。
DOI：
10.1111/j.1747-0285.2011.01274.x
复制
发表时间：
2012
影响因子：
3
通讯作者：
Hines,JenniferV
中科院分区：
文献类型：
--
作者：
Zhou,Shu;Acquaah-Harrison,George;Jack,KarenD;Bergmeier,StephenC;Hines,JenniferV
The T box antiterminator RNA element is an important component of the T box riboswitch that controls the transcription of vital genes in many Gram‐positive bacteria. A series of 1,4‐disubstituted 1,2,3‐triazoles was screened in a fluorescence‐monitored thermal denaturation assay to identify ligands that altered the stability of antiterminator model RNA. Several ligands were identified that significantly increased or decreased the melting temperature (Tm) of the RNA. The results indicate that this series of triazole ligands can alter the stability of antiterminator model RNA in a structure‐dependent manner.
