Antenatal dexamethasone administration impairs normal postnatal lung growth in rats
Antenatal dexamethasone administration impairs normal postnatal lung growth in rats
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DOI：
10.1203/00006450-200106000-00011
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发表时间：
2001-06-01
影响因子：
3.6
通讯作者：
Fujimoto, S
中科院分区：
文献类型：
--
作者：
Okajima, S;Matsuda, T;Fujimoto, S
本研究旨在探讨产前应用地塞米松对新生大鼠肺发育的影响。地塞米松每天0.4 mg/kg。定时妊娠SD大鼠于孕21d(第1组)或第20、21d(第2组)。自然分娩后，取1-60d仔猪的肺进行形态计量学分析。在60d龄仔鼠中，第1组和第2组的肺泡数密度均低于对照组，而平均肺泡半径大于对照组。大鼠出生前给予地塞米松会损害正常的出生后肺生长。人类产前使用糖皮质激素治疗的某些方面可能需要重新考虑。
Our purpose was to determine the influences of antenatal dexamethasone administration on neonatal lung development in rats. Dexamethasone (0.4 mg/kg maternal body weight per day) was administered i.p. on the 21st d (group 1) or on the 20th and 21st d (group 2) of gestation in Sprague Dawley rats with timed pregnancies. After natural deliveries, the lungs of the pups 1-60 d of age were removed and processed for morphometric analysis. In 60-d-old pups, groups 1 and 2 both showed a lower numerical density of alveoli and a larger mean alveolar radius than control pups. Antenatal administration of dexamethasone to rats impairs the normal postnatal lung growth. Some aspects of the use of antenatal glucocorticoid therapy in humans may require reconsideration.