Citicoline improves verbal memory in aging
Citicoline improves verbal memory in aging
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DOI：
10.1001/archneur.1996.00550050071026
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发表时间：
1996-05-01
影响因子：
--
通讯作者：
Wurtman, RJ
中科院分区：
文献类型：
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作者：
Spiers, PA;Myers, D;Wurtman, RJ
目的：设计：在最初的研究中采用了随机、双盲、安慰剂对照、平行组设计。经过数据分析后，确定了一个小组，其成员的记忆力相对较低。这些受试者被招募用于使用交叉设计的第二项研究。受试者在初始研究中服用安慰剂或胞二磷胆碱，1000 mg/d，持续3个月。在交叉研究中，受试者服用安慰剂和胞二磷胆碱，2000 mg/d，各2个月。他们接受了痴呆症、记忆障碍和其他神经系统问题的筛查。在记忆力相对较差的受试者中，有32人参加了交叉研究。主要结果测量：在每次研究访问时，使用逻辑记忆通道测试言语记忆。在基线、初始研究第30、60和90天以及交叉研究中每种治疗条件第60天测量血浆胆碱浓度。血浆胆碱浓度和记忆分数进行了分析，使用重复测量方差和协方差分析，然后通过计划比较时，适当的.Results：在最初的研究中，胞磷胆碱治疗改善延迟回忆逻辑记忆只有相对低效的记忆主体。在交叉研究中，更高剂量的胞磷胆碱明显与改善即时和延迟逻辑memory.Conclusions：胞磷胆碱治疗改善了文字记忆功能的老年人相对低效的记忆。胞磷胆碱可能被证明在治疗与年龄相关的认知能力下降方面是有效的，这可能是痴呆症的前兆。
Objective: To test the verbal memory of older volunteers given citicoline.Design: A randomized, double-blind, placebo-controlled, parallel group design was employed in the initial study. After data analysis, a subgroup was identified whose members had relatively inefficient memories. These subjects were recruited for a second study that used a crossover design. The subjects took either placebo or citicoline, 1000 mg/d, for 3 months in the initial study. In the crossover study, subjects took both placebo and citicoline, 2000 mg/d, each for 2 months.Subjects: The subjects were 47 female and 48 male volunteers 50 to 85 years old. They were screened for dementia, memory disorders, and other neurological problems. Of the subjects with relatively inefficient memories, 32 participated in the crossover study.Main Outcome Measure: Verbal memory was tested at each study visit using a logical memory passage. Plasma choline concentrations were measured at baseline; at days 30, 60, and 90 in the initial study; and at day 60 of each treatment condition in the crossover study. Plasma choline concentrations and memory scores were analyzed using repeated-measures analysis of variance and covariance, followed by planned comparisons when appropriate.Results: In the initial study, citicoline therapy improved delayed recall on logical memory only for the subjects with relatively inefficient memories. In the crossover study, the higher dosage of citicoline was clearly associated with improved immediate and delayed logical memory.Conclusions: Citicoline therapy improved verbal memory functioning in older individuals with relatively inefficient memories. Citicoline may prove effective in treating age-related cognitive decline that may be the precursor of dementia.