Long-term immune dysfunction in rainbow trout (Oncorhynchus mykiss) exposed as embryos to aflatoxin B1.
Long-term immune dysfunction in rainbow trout (Oncorhynchus mykiss) exposed as embryos to aflatoxin B1.
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胚胎时期暴露于黄曲霉毒素 B1 的虹鳟鱼 (Oncorhynchus mykiss) 出现长期免疫功能障碍。
DOI：
10.1006/fsim.1999.0227
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Kaattari,SL
中科院分区：
文献类型：
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作者：
Ottinger,CA;Kaattari,SL
霉菌毒素黄曲霉毒素B1(AFB1)是一种多环芳烃(PAH)，与多种脊椎动物的肝癌发生和免疫调节有关(Ottinger&Kaattari，1998)。在虹鲑鱼中，AFB1通过与哺乳动物相似的途径转化为具有生物活性的形式。AFB1被细胞色素P450家族的酶转化为AFB1-8，9，-环氧化物(Loveland等人，1987)(Bailey等人，1984)。这种环氧化物与DNA共价结合，形成8，9-二氢-8-(N7-鸟苷)-9-羟基黄曲霉毒素B1(Croy等，1980；Croy&Wogan 1981)。黄曲霉毒素与芳香烃受体结合及随后的信号转导后细胞色素P450 mRNA合成上调
The mycotoxin, aflatoxin B1 (AFB1), is a polycyclic aromatic hydrocarbon (PAH) that is associated with hepatic carcinogenesis and immunomodulation in a broad spectrum of vertebrates (Ottinger & Kaattari, 1998). In rainbow trout, the transformation of AFB1 to a biologically active form occurs via pathways similar to those in mammals. AFB1 is transformed to AFB1-8, 9,-epoxide (Loveland et al., 1987) by enzymes of the cytochrome P450 family (Bailey et al., 1984). This epoxide covalently binds to DNA to form 8, 9-dihydro-8-(N7-guany)-9-hydroxyaflatoxin B1 (Croy et al., 1980; Croy & Wogan 1981). Up-regulation of cytochrome P450 mRNA synthesis occurs following aflatoxin binding to the aromatic hydrocarbon receptor and subsequent signal transduction