RADIOSENSITIZATION OF HYPOXIC TUMOR-CELLS BY DEPLETION OF INTRACELLULAR GLUTATHIONE
RADIOSENSITIZATION OF HYPOXIC TUMOR-CELLS BY DEPLETION OF INTRACELLULAR GLUTATHIONE
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DOI：
10.1126/science.7089580
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
BROWN, JM
中科院分区：
文献类型：
--
作者：
BUMP, EA;YU, NY;BROWN, JM
在体外，马来酸二乙酯消耗中国仓鼠卵巢细胞中的谷胱甘肽，导致 X 射线在缺氧条件下对细胞存活的影响增强，但在含氧条件下则不然。缺氧的 EMT6 肿瘤细胞在体内也有类似的致敏作用。马来酸二乙酯的作用与电子亲和放射增敏剂米索硝唑的作用具有协同作用，表明米索硝唑与消耗细胞内谷胱甘肽的药物联合使用可能会提高癌症放射治疗的效果。
Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of X-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.