Long-term effects of nicotine gum on weight gain after smoking cessation.
Long-term effects of nicotine gum on weight gain after smoking cessation.
复制标题
尼古丁口香糖对戒烟后体重增加的长期影响。
DOI：
10.1080/14622299050011381
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Garvey,AJ
中科院分区：
文献类型：
--
作者：
Nordstrom,BL;Kinnunen,T;Utman,CH;Garvey,AJ
戒烟通常会导致体重增加。人们发现尼古丁口香糖疗法在戒烟后的头几个月可以减少体重增加，但其长期效果尚不完全清楚。目前的研究随机分配608名吸烟者接受安慰剂、2毫克或4毫克尼古丁口香糖。在之前的一篇论文[Doherty， Militello, Kinnunen, & Garvey (1996)， Journal of Consulting and Clinical Psychology 64:799-807]中报道的短期体重变化结果的后续分析中，我们研究了92名戒烟1年后尼古丁口香糖对体重变化的影响。我们发现体重变化随口香糖剂量（活性口香糖和安慰剂）而有所不同，但体重变化似乎更强烈地依赖于戒烟前可替宁水平被尼古丁口香糖所取代的百分比。在牙龈治疗期间替代戒烟前较高比例的可替宁的参与者在戒烟后的第一年体重增加较少，而替代90%以上可替宁的参与者在戒烟后一年内体重仅增加1.7公斤。这些发现表明，未来的研究有必要确定足够高水平的尼古丁替代品是否有助于永久减少戒烟引起的体重增加。
Smoking cessation usually results in weight gain. Nicotine gum therapy has been found to reduce weight gain in the first months after cessation, but its long-term effects are not fully known. The present study randomly assigned 608 smokers to receive placebo, 2 or 4 mg nicotine gum. In a follow-up analysis to the short-term weight change results reported in a previous paper [Doherty, Militello, Kinnunen, & Garvey (1996), Journal of Consulting and Clinical Psychology 64:799–807], we examined the effects of the nicotine gum on weight change for 1 year after cessation among the 92 1-year abstainers. We found that weight change showed some variation with gum dose (active vs. placebo), but that weight change appeared to depend more strongly on the percentage of pre-cessation cotinine levels replaced by the nicotine gum. Participants who replaced higher proportions of their pre-cessation cotinine during the gum therapy period gained less weight during the first year post-cessation than those who replaced less cotinine, with those who replaced greater than 90% of their cotinine gaining only 1.7 kg by 1 year post-cessation. These findings suggest that future research is warranted to determine whether sufficiently high levels of nicotine replacement can help to permanently reduce cessation-related weight gain.