Immunophenotypic analysis of the p53 gene in non‐melanoma skin cancer and correlation with apoptosis and cell proliferation

Immunophenotypic analysis of the p53 gene in non‐melanoma skin cancer and correlation with apoptosis and cell proliferation
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非黑色素瘤皮肤癌p53基因的免疫表型分析及其与细胞凋亡和细胞增殖的相关性

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发表时间:
2005
影响因子:
9.2
通讯作者:
A. Katsambas
A. Katsambas
中科院分区:
医学2区
文献类型:
--
作者:
A. Stratigos;N. Kapranos;E. Petrakou;A. Anastasiadou;A. Pagouni;E. Christofidou;A. Petridis;O. Papadopoulos;E. Kokka;C. Antoniou;S. Georgala;A. Katsambas

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背景   阳光会引发一系列遗传事件,导致基底细胞癌 (BCC) 和鳞状细胞癌 (SCC) 等皮肤癌的发生。 p53 抑癌基因在细胞分裂和细胞凋亡中发挥着关键作用,经常在阳光诱发的皮肤肿瘤中发现突变。
Background   Sunlight precipitates a series of genetic events that lead to the development of skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The p53 tumour suppressor gene, which plays a pivotal role in cell division and apoptosis, is frequently found mutated in sunlight‐induced skin tumours.
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影响因子: 11.1
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