Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area
Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area
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DOI：
10.1530/eje-09-0410
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发表时间：
2009-10-01
影响因子：
5.8
通讯作者：
Tutuncu, Neslihan Bascil
中科院分区：
文献类型：
--
作者：
Ayturk, Semra;Gursoy, Alptekin;Tutuncu, Neslihan Bascil
目的：代谢综合征（MetS）是一组代谢异常伴胰岛素抵抗（IR）的主要组成部分。MetS及其相关成分是否与甲状腺的功能和形态改变有关，最近一直受到质疑。本研究的目的是在轻度至中度缺碘地区的MetS患者的病例对照研究中检查甲状腺体积和结节患病率。设计：278名MetS患者与261名非MetS患者随机匹配年龄、性别和吸烟习惯。血清TSH。游离三碘甲状腺原氨酸和甲状腺素，以及IR水平，这是通过IR稳态模型评估估计的。并对其其他MetS参数进行了评估。所有受试者均行甲状腺超声检查。所有甲状腺结节直径为10 ~ 1cm的患者均行甲状腺细针穿刺活检。结果：TSH与met诊断呈显著正相关。游离甲状腺激素水平与MetS及其相关成分之间没有关联。met患者的平均甲状腺体积显著高于对照组(17.5 +/- 5.5 vs 12.2 +/- 4.2 ml， P
Objective: Metabolic syndrome (MetS) is it cluster of metabolic abnormalities with insulin resistance (IR) its it major component. It has been recently questioned whether MetS and its related components are associated with functional and morphological alterations of the thyroid gland. The aim Of Our Study is to examine thyroid Volume and nodule prevalence in a case-control study of patients with MetS in it mild-to-moderate iodine-deficient area.Design: Two hundred and seventy-eight patients with MetS were randomly matched for age, gender, and smoking habits with 261 Subjects without MetS. Serum TSH. Free tri-iodothyronine and thyroxine, and the level of IR, which was estimated by the homeostasis model assessment For IR. as well its other MetS parameters were evaluated. Thyroid Ultrasonography was performed in all Subjects. All subjects with thyroid nodules >1 cm were offered to undergo thyroid fine needle aspiration biopsy.Results: TSH was significantly positively correlated with the presence of MetS diagnosis. There was no association between free thyroid hormone levels and MetS and its related components. Mean thyroid volume was significantly higher in patients with MetS than in controls (17.5 +/- 5.5 vs 12.2 +/- 4.2 ml, P