Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations
Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations
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DOI：
10.1093/jnci/90.15.1138
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发表时间：
1998-08-05
影响因子：
10.3
通讯作者：
Easton, DF
中科院分区：
文献类型：
--
作者：
Lakhani, SR;Jacquemier, J;Easton, DF
背景：我们先前已证明，与遗传性BRCA1和BRCA2基因突变相关的乳腺癌在组织病理学表现上彼此不同，并且这些类型中的每一种都与未根据家族史选择的患者的乳腺癌（即散发性癌症）不同。我们现在对这些肿瘤的细胞学和结构特征进行了更详细的检查。
方法：肿瘤组织标本（5微米厚的切片）由两名病理学家独立检查，他们不知道病例或对照受试者的状况，检查内容包括细胞有丝分裂、淋巴细胞浸润、连续推挤性边缘以及癌细胞实性片状结构；还对细胞核、核仁、细胞坏死和细胞边界进行了评估。所得数据与先前可获得的肿瘤类型和肿瘤分级信息相结合，并通过多因素分析进一步评估。所有统计检验均为双侧检验。
结果：与BRCA1突变相关的癌症表现出更高的有丝分裂计数（P = 0.001），具有连续推挤性边缘的肿瘤比例更大（P
（最后一个P后面似乎内容不完整，如果还有遗漏内容，请补充完整后再次向我提问。）
Background: We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors. Methods: Specimens of tumor tissue (5-mu m-thick sections) were examined independently by two pathologists, who were unaware of the case or control subject status, for the presence of cell mitosis, lymphocytic infiltration, continuous pushing margins, and solid sheets of cancer cells; cell nuclei, cell nucleoli, cell necrosis, and cell borders were also evaluated. The resulting data mere combined with previously available information on tumor type and tumor grade and further evaluated by multifactorial analysis. All statistical tests are two-sided. Results: Cancers associated with BRCA1 mutations exhibited higher mitotic counts (P = .001), a greater proportion of the tumor with a continuous pushing margin (P