On possible role of DNA electrodynamics in chromatin regulation.
On possible role of DNA electrodynamics in chromatin regulation.
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DOI：
10.1016/j.pbiomolbio.2017.12.006
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发表时间：
2017-12
影响因子：
3.8
通讯作者：
O. Polesskaya;Vadim V. Guschin;N. Kondratev;Irina A. Garanina;O. Nazarenko;N. Zyryanova;A. Tovmash;Abraham Mara;Tatiana Shapiro;E. Erdyneeva;Yue Zhao;Eugenia Y Kananykhina;Max Myakishev-Rempel
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文献类型：
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作者：
O. Polesskaya;Vadim V. Guschin;N. Kondratev;Irina A. Garanina;O. Nazarenko;N. Zyryanova;A. Tovmash;Abraham Mara;Tatiana Shapiro;E. Erdyneeva;Yue Zhao;Eugenia Y Kananykhina;Max Myakishev-Rempel
尽管进行了广泛的研究，基因调控仍然没有完全理解。虽然所有主要的转录因子，基因启动子序列和调控元件已被彻底的特点，我们的能力预测基因的转录水平是非常有限的。Even Genomatix（Patel等人，2012年），在基因启动子分析的领导者在过去的16年，仍然有有限的能力来预测基因的转录的基础上，其调控序列和转录因子的存在。我们和其他人假设，这种关于基因转录的不确定性不是由基因调控的复杂性引起的，而是由于对基因调控机制的不完全理解。换句话说，基因启动子可能含有尚未破译的信号，这些信号既不受转录因子的调节，也不受任何其他化学手段的调节，而是通过下面讨论的另一种原理进行调节。“关于人类基因组最令人惊讶的发现是大多数功能序列不编码蛋白质，”（Lander，2011）反映了Eric Lander对人类基因组测序的看法（Lander和国际人类基因组测序联盟，2001）。具体而言，除了基因组中1.5%的蛋白质编码序列外，还有6%的序列虽然不编码蛋白质，但也是保守的，因此具有重要的生物学功能（Lander，2011）。现在，在人类基因组首次测序16年后，大多数功能性非转录序列的功能仍然未知。这有力地表明，还存在未知的机制，未转录序列发挥其功能。我们认为这种未知的基因调控机制本质上是电性的。
In spite of extensive research, gene regulation is still not fully understood. Although all major transcription factors, gene promoter sequences and regulatory elements have been thoroughly characterized, our ability to predict transcription levels of genes is very limited. Even Genomatix (Patel et al., 2012), the leader in gene promoter analysis for the last 16 years, still has limited ability to predict the transcription of genes based on their regulatory sequences and the presence of transcription factors. It is hypothesized by us and others that this uncertainty regarding gene transcription is caused not by the complexity of gene regulation but by an incomplete understanding of the mechanisms of gene regulation. In other words, gene promoters may contain yet undeciphered signals which are regulated neither by transcription factors nor by any other chemical means but via another principle discussed below.Comparative genomics also suggests that additional yet unknown regulatory mechanisms are in place.“The most surprising discovery about the human genome was that the majority of the functional sequence does not encode proteins,”(Lander, 2011) reflected Eric Lander on the sequencing of the human genome (Lander and International Human Genome Sequencing Consortium, 2001). Specifically, in addition to 1.5% protein coding sequences in the genome, there are 6% of sequences which, though they do not code for proteins, are also conserved and therefore would have an important biological function (Lander, 2011). Now, 16 years after the initial sequencing of the human genome, the functions of the majority of functional untranscribed sequences are still unknown. This strongly suggests that there are yet unknown mechanisms by which untranscribed sequences exert their function. We suggest here that this unknown mechanism of gene regulation is electrical in nature.