Blood cell proliferation response to beryllium: analysis by receiver-operating characteristics.
Blood cell proliferation response to beryllium: analysis by receiver-operating characteristics.
复制标题
血细胞对铍的增殖反应：通过接受者操作特征进行分析。
DOI：
10.1097/00043764-199101000-00009
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Rossman,MD
中科院分区：
文献类型：
--
作者：
Stokes,RF;Rossman,MD
由于铍诱导的支气管肺泡灌洗细胞增殖测试不适合用于筛查，因此我们评估了血细胞对铍的增殖反应。将 27 名患有慢性铍病的患者与 30 名对照者进行比较，这些患者经组织学记录且对铍有阳性肺增殖反应。在铍病患者和使用 100 或 10 μM 铍盐的对照组之间观察到显着差异 (P < .05)。为了评估最佳测试参数和刺激指数截止值，生成了接收者操作特征曲线（真阳性与假阳性）。在刺激指数截止值为 2.5 时观察到最大预测阳性值 (26%)，这对应于 38% 的敏感性和 97% 的特异性。这表明血细胞对铍的增殖反应在筛查慢性铍病中的作用有限。
As testing for beryllium-induced proliferation of bronchoalveolar lavage cells is not suitable for screening, we evaluated the proliferative response of blood cells to beryllium. Twenty-seven patients with chronic beryllium disease, documented by histology and a positive lung proliferative response to beryllium, were compared to 30 controls. A signifícant difference (P < .05) was observed between beryllium disease patients and controls with 100 or 10 μM beryllium salts. To evaluate the optimum test parameters and stimulation index cutoff, receiver operating characteristic curves (true positive v false positive) were generated. Maximum predictive value positive (26%) was observed at a stimulation index cutoff of 2.5, which corresponds to a 38% sensitivity and 97% specificity. This suggests that the blood cell proliferation response to beryllium has a limited role in screening for chronic beryllium disease.