Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer
Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer
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Ku80基因G-1401T启动子多态性与胃癌风险
DOI：
10.3748/wjg.v17.i16.2131
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发表时间：
2011-04-28
影响因子：
4.3
通讯作者：
Wang, Xue-Rong
中科院分区：
文献类型：
--
作者：
Li, Jia-Qi;Chen, Jie;Wang, Xue-Rong
目的：探讨中国胃癌患者Ku80基因多态性与胃癌发病的关系。方法：在江苏省以医院为基础的胃癌病例对照研究中，研究Ku80 G-1401T （rs828907）多态性与胃癌发病风险的关系。采用聚合酶链反应-限制性片段长度多态性对241例胃癌患者和273例年龄和性别匹配的对照组进行基因分型分析。结果：胃癌患者中GG、GT、TT基因型频率分别为65.6%、22.8%、11.6%，对照组中分别为75.8%、17.6%、6.6%。胃癌组与对照组Ku80启动子G-1401T多态性基因型分布（P = 0.03）和等位基因频率（P = 0.002）差异有统计学意义。结论：Ku80 G-1401T的T等位基因可能与胃癌的发生发展有关。(C) 2011年白石登。版权所有。
AIM: To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.METHODS: In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.RESULTS: The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.CONCLUSION: The T allele of Ku80 G-1401T may be associated with the development of gastric cancer. (C) 2011 Baishideng. All rights reserved.