The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs
The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs
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DOI：
10.1093/jn/136.5.1161
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Fernandez, ML
中科院分区：
文献类型：
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作者：
Herron, KL;McGrane, MM;Fernandez, ML
ATP结合盒G5（ABCG 5）多态性已被假定在对膳食胆固醇的反应中发挥作用。本研究的目的是检查ABCG 5多态性对食用鸡蛋中胆固醇和类胡萝卜素的血浆反应的贡献。为此目的，对40名男性和51名绝经前女性进行基因分型，这些女性被随机分配食用鸡蛋（EGG，640 mg/d额外的膳食胆固醇和600 μ g叶黄素+玉米黄质）或安慰剂（EGG，0 mg/d胆固醇，0 μ g叶黄素+玉米黄质）饮食30天。饮食干预的两个臂被3周的洗脱期分开。测定总胆固醇、LDL胆固醇（LDL-C）和HDL胆固醇的血浆浓度。由于鸡蛋是叶黄素和玉米黄质的极好来源，因此还在一部分受试者中测量了这些类胡萝卜素的血浆水平，以确定对类胡萝卜素摄入的反应是否与膳食胆固醇相似，并评估ABCG 5多态性对这两种反应的贡献。与C/G（杂合子）或G/G基因型（纯合子）的个体相比，具有C/C基因型的个体在EGG期间经历了LDL-C（P < 0.05）和叶黄素趋势（P = 0.08）的更大增加。这些结果，虽然从少数受试者中获得，表明ABCG 5多态性可能在血浆对膳食胆固醇和类胡萝卜素的反应中发挥作用。
The ATP binding cassette G5 (ABCG5) polymorphisms have been postulated to play a role in the response to dietary cholesterol. The objective of this study was to examine the contribution of the ABCG5 polymorphism on the plasma response to consumption of cholesterol and carotenoids from eggs. For this purpose, genotyping was conducted for 40 men and 51 premenopausal women who were randomly assigned to consume an egg (EGG, 640 mg/d additional dietary cholesterol and 600 mu g lutein + zeaxanthin) or placebo (SUB, 0 mg/d cholesterol, 0 mu g lutein + zeaxanthin) diet for 30 d. The two arms of the dietary intervention were separated by a 3-wk washout period. Plasma concentrations of total cholesterol, LDL cholesterol (LDL-C), and HDL cholesterol were determined. Because eggs are an excellent source of lutein and zeaxanthin, the plasma levels of these carotenoids were also measured in a subset of subjects to determine whether the response to carotenoid intake was similar to that seen for dietary cholesterol and to evaluate the contribution of ABCG5 polymorphism to both responses. Individuals possessing the C/C genotype experienced a greater increase in both LDL-C (P < 0.05) and a trend for lutein (P = 0.08) during the EGG period compared with those individuals with the C/G (heterozygote) or G/G genotypes (homozygotes). These results, although obtained from a small number of subjects, suggest that the ABCG5 polymorphism may play a role in the plasma response to dietary cholesterol and carotenoids.