Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin
Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin
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DOI：
10.1111/j.1365-2036.2007.03288.x
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发表时间：
2007-05-01
影响因子：
7.6
通讯作者：
Malagelada, J. -R.
中科院分区：
文献类型：
--
作者：
Casellas, F.;Borruel, N.;Malagelada, J. -R.
背景菊粉和低聚果糖促进糖分解菌的选择性生长，具有低炎症潜能。目的检测低聚果糖富集菊粉对活动性溃疡性结肠炎患者的影响。设计前瞻性、随机、安慰剂对照的先导性试验。符合条件的患者以前曾接受美沙拉秦维持治疗或未接受药物治疗，病情缓解，但出现轻度至中度活动复发。他们接受美沙拉秦（3克/天）治疗，并随机分配接受富含低聚果糖的菊粉（12克/天，口服，n = 10）或安慰剂（12 g/天麦芽糖糊精，p.o.，n = 9）2周。结果两组患者的Rachmilewitz评分均较治疗前降低，第14天差异有统计学意义（P < 0.05），第14天差异有统计学意义（P < 0.05）。富含低聚果糖的菊粉耐受性良好，消化不良症状量表在积极治疗组显著降低，但安慰剂组无此作用。在第7天，在接受富含低聚果糖的菊粉的组中观察到钙卫蛋白的早期显著减少（第0天：4377 +/- 659 μ g/g;第7天：1033 +/- 393 μ g/g，P < 0.05），但安慰剂组中没有（第0天：5834 +/- 1563 μ g/g;第7天：4084 +/- 1395 μ g/g，n.s.）。人类DNA粪便浓度的变化并不显着。结论在活动性溃疡性结肠炎，饮食补充低聚果糖富集菊粉是耐受性良好，并与早期减少粪便钙卫蛋白。
Background Inulin and oligofructose promote selective growth of saccharolytic bacteria with low inflammatory potential.Objective To test the effect of oligofructose-enriched inulin in patients with active ulcerative colitis.Design Prospective, randomized, placebo controlled pilot trial. Eligible patients had been previously in remission with mesalazine as maintenance therapy or no drug, and presented with a relapse of mild to moderate activity. They were treated with mesalazine (3 g/day) and randomly allocated to receive either oligofructose-enriched inulin (12 g/day, p.o., n = 10) or placebo (12 g/day of maltodextrin, p.o., n = 9) for 2 week. Primary endpoint was the anti-inflammatory effect as determined by reduction of calprotectin and human DNA in faeces.Results Rachmilewitz score decreased in both groups, reaching statistical significance at day 14 (P < 0.05). Oligofructose-enriched inulin was well-tolerated and dyspeptic symptoms scale decreased significantly with active treatment but not with placebo. At day 7, an early significant reduction of calprotectin was observed in the group receiving oligofructose-enriched inulin (day 0: 4377 +/- 659 mu g/g; day 7: 1033 +/- 393 mu g/g, P < 0.05) but not in the placebo group (day 0: 5834 +/- 1563 mu g/g; day 7: 4084 +/- 1395 mu g/g, n.s.). Changes in faecal concentration of human DNA were not significant.Conclusion In active ulcerative colitis, dietary supplementation with oligofructose-enriched inulin is well tolerated and is associated with early reduction in faecal calprotectin.