Total Synthesis of (−)-Ambiguine P
Total Synthesis of (−)-Ambiguine P
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()-Ambiguine P 的全合成
DOI：
10.1021/jacs.9b01739
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发表时间：
2019
影响因子：
15
通讯作者：
Rawal, V. H.
中科院分区：
文献类型：
--
作者：
Xu, J.;Rawal, V. H.
描述了 (-)-模糊 P 的简明全合成，(-)-模糊 P 是 hapalindole 生物碱的一种含环庚烷成员。通过[4 + 3]环加成反应启发的策略快速组装天然产物具有挑战性的五环框架，并通过NBS介导的溴化亲核取代序列引入叔羟基。
Described is a concise total synthesis of (−)-ambiguine P, a cycloheptane-containing member of the hapalindole alkaloids. The challenging pentacyclic framework of the natural product was assembled rapidly via a [4 + 3] cycloaddition reaction-inspired strategy, and the tertiary hydroxy group was introduced by an NBS-mediated bromination–nucleophilic substitution sequence.