Maternal serum folate species in early pregnancy and risk of preterm birth
Maternal serum folate species in early pregnancy and risk of preterm birth
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DOI：
10.3945/ajcn.2010.29675
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发表时间：
2010-10-01
影响因子：
7.1
通讯作者：
Simhan, Hyagriv N.
中科院分区：
文献类型：
--
作者：
Bodnar, Lisa M.;Himes, Katherine P.;Simhan, Hyagriv N.
背景：母亲叶酸状况不佳与早产风险增加有关。然而，我们对个别叶酸种类与早产之间关系的理解仍存在重大差距。目的：我们的目的是评估通过 5-甲基四氢叶酸 (5MeTHF)、5-甲酰四氢叶酸 (5FoTHF) 和叶酸浓度（血清中 3 个主要叶酸种类）测量的母体叶酸状态与早产和自发性早产 (sPTB) 风险之间的关系。 313 名在 Magee-Womens 医院（宾夕法尼亚州匹兹堡）住院产前诊所接受护理的孕妇（2003-2007 年）被纳入
Background: Poor maternal folate status has been associated with an increased risk of preterm birth. However, major gaps remain in our understanding of how individual folate species relate to preterm birth.Objective: Our objective was to assess the association between maternal folate status as measured by 5-methyltetrahydrofolate (5MeTHF), 5-formyltetrahydrofolate (5FoTHF), and folic acid concentrations, which are the 3 primary folate species in serum, and the risk of preterm birth and spontaneous preterm birth (sPTB).Design: A cohort of 313 pregnant women who received care at resident antepartum clinics at Magee-Womens Hospital (Pittsburgh, PA) (2003-2007) was enrolled at