Distribution of nerve fibers immunoreactive to neurofilament protein in rat molars and periodontium
Distribution of nerve fibers immunoreactive to neurofilament protein in rat molars and periodontium
复制标题
大鼠磨牙和牙周组织中神经丝蛋白免疫反应性神经纤维的分布
DOI：
10.1007/bf00215413
复制
发表时间：
1987
影响因子：
3.6
通讯作者：
Shigeo Kobayashi
中科院分区：
文献类型：
--
作者：
T. Maeda;T. Iwanaga;T. Fujita;Y. Takahashi;Shigeo Kobayashi
SummaryThe distribution of nerve fibers in molars, periodontal ligament and gingiva of the rat shows a complex pattern. Decalcified material including the alveolar bone was sectioned in three different planes and stained by means of immunohistochemistry for detection of the neurofilament protein (NFP); the immunoreactive neural elements were clearly visualized in three-dimensional analyses. NFP-positive nerve fibers formed a subodontoblastic plexus in the roof area of the dental pulp; some of them entered the predentin and dentin directly through the dentinal tubules. This penetration was found mainly in the pulp horn, and was limited to a distance of about 100 μm from the pulpo-dentinal junction. In the periodontal ligament, NFP-positive nerve fibers were found densely distributed in the lower half of the alveolar socket. Two types of nerve terminals were recognized in the periodontal ligament: free nerve endings with tree-like ramifications, and expanded nerve terminals showing button- or glove-like shapes. The former tapered among the periodontal fibers, some even reaching the cementoblastic layer. The latter were located, frequently in groups, within the ligament restricted to the lower third of the alveolar socket. A well-developed plexus of NFP-positive nerves was revealed in the lamina propria of the free gingiva, the innervation being denser toward the epithelium of the gingival crevice. The characteristic distribution of NFP-immunoreactive nerve fibers revealed in this study is discussed in relation to region-specific sensations in the teeth and surrounding tissues.
