Evidence of a Systemic Predisposition to Chondrocalcinosis and Association Between Chondrocalcinosis and Osteoarthritis at Distant Joints: A Cross-Sectional Study
Evidence of a Systemic Predisposition to Chondrocalcinosis and Association Between Chondrocalcinosis and Osteoarthritis at Distant Joints: A Cross-Sectional Study
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DOI：
10.1002/acr.21952
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发表时间：
2013-07-01
影响因子：
4.7
通讯作者：
Doherty, M.
中科院分区：
文献类型：
--
作者：
Abhishek, A.;Doherty, S.;Doherty, M.
目的探讨软骨钙化症（CC）是否具有全身性易感性，并探讨CC与远处关节骨关节炎（OA）的关系。方法我们在骨关节炎遗传学和生活方式（GOAL）数据库中进行了一项横断面研究（n = 3170）。所有GOAL参与者都进行了膝关节、手部和骨盆的x线片检查。对膝关节、髋关节、腕关节和掌指关节（MCP）的OA和膝关节、髋关节、腕关节和耻骨联合关节的CC以及MCP关节钙化进行评分。采用聚类分析确定了CC的系统性易感性。比值比（95%置信区间）用于检查指数关节和远关节的CC、同一关节的CC和OA以及指数关节的OA和远关节CC之间的关系。我们调整了年龄、性别和体重指数，如果需要，还调整了远关节OA。结果具有CC的关节聚集在一起。当OA患者被排除在分析之外时，也观察到这一点。每个关节的CC与远处关节的CC相关。膝关节和腕部OA与同一关节的CC相关，但与髋部OA无关。MCP关节OA与MCP关节钙化有关。膝关节OA与其他关节的CC相关，与远端关节的OA无关。结论散发性CC具有全身性易感性，除髋部OA与髋部CC和远端关节CC无相关性外，OA与同一关节和远端关节CC均有相关性。
ObjectiveTo determine whether there is a systemic predisposition to chondrocalcinosis (CC) and to examine the association between CC and osteoarthritis (OA) at distant joints.MethodsWe performed a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle (GOAL) database (n = 3,170). All GOAL participants have had radiographs of the knees, hands, and pelvis performed. These were scored for OA at the knee, hip, wrist, and metacarpophalangeal (MCP) joints and for CC at the knee, hip, wrist, and symphysis pubis joints and for MCP joint calcification. Systemic predisposition to CC was established using cluster analysis. Odds ratios (95% confidence intervals) were used to examine the association between CC at the index and distant joints, CC and OA at the same joint, and index joint OA and distant joint CC. We adjusted for age, sex, and body mass index, and for distant joint OA, if required.ResultsJoints with CC clustered together. This was also observed when participants with OA were excluded from the analysis. CC at each joint was associated with CC at distant joints. Knee and wrist OA but not hip OA was associated with CC at the same joint. MCP joint OA was associated with MCP joint calcification. Knee OA was associated with CC at other joints, and this was independent of OA at the distant joint. There was no association between hip OA and distant joint CC.ConclusionThere is a systemic predisposition to the apparently sporadic CC. OA is associated with CC at the same joint and at distant joints, except hip OA, which is not associated with hip CC or with CC at distant joints.