On the origin of Tibetans and their genetic basis in adapting high-altitude environments.
On the origin of Tibetans and their genetic basis in adapting high-altitude environments.
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DOI：
10.1371/journal.pone.0017002
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Wang B;Zhang YB;Zhang F;Lin H;Wang X;Wan N;Ye Z;Weng H;Zhang L;Li X;Yan J;Wang P;Wu T;Cheng L;Wang J;Wang DM;Ma X;Yu J
新石器时代到达青藏高原后，藏族人已经很好地适应了极端的环境条件，并拥有反映其生活环境和迁徙历史的遗传变异。为了探讨藏族的起源和在严酷环境中适应的遗传基础，我们用超过100万个SNP标记对30个藏族个体进行了基因分型。我们的研究结果表明，藏人与彝族一起，是从东亚古代定居者中分离出来的藏缅人的后代。横断山脉的山谷可能是一条主要的迁徙路线。我们还确定了一组积极选择的基因，属于胚胎，雌性性腺和血管发育的功能类，以及对缺氧的反应。这些基因中的大多数与人群特异性和有益的表型高度相关，例如高婴儿存活率和无慢性高原病。
Since their arrival in the Tibetan Plateau during the Neolithic Age, Tibetans have been well-adapted to extreme environmental conditions and possess genetic variation that reflect their living environment and migratory history. To investigate the origin of Tibetans and the genetic basis of adaptation in a rigorous environment, we genotyped 30 Tibetan individuals with more than one million SNP markers. Our findings suggested that Tibetans, together with the Yi people, were descendants of Tibeto-Burmans who diverged from ancient settlers of East Asia. The valleys of the Hengduan Mountain range may be a major migration route. We also identified a set of positively-selected genes that belong to functional classes of the embryonic, female gonad, and blood vessel developments, as well as response to hypoxia. Most of these genes were highly correlated with population-specific and beneficial phenotypes, such as high infant survival rate and the absence of chronic mountain sickness.
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影响因子：
7
作者：
Pickrell, Joseph K.;Coop, Graham;Pritchard, Jonathan K.
通讯作者：
Pritchard, Jonathan K.
影响因子：
14.9
作者：
Benita Y;Kikuchi H;Smith AD;Zhang MQ;Chung DC;Xavier RJ
通讯作者：
Xavier RJ
DOI：
10.1073/pnas.1002443107
发表时间：
2010-06-22
影响因子：
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作者：
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通讯作者：
Zheng, Yong Tang
DOI：
10.1038/nrg2632
发表时间：
2009-11
期刊：
Nature reviews. Genetics
影响因子：
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作者：
通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
Herrera, Rene J.