Preparation and characteristics of pH‐sensitive derivated dextran hydrogel nanoparticles
Preparation and characteristics of pH‐sensitive derivated dextran hydrogel nanoparticles
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DOI：
10.1002/pc.20684
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发表时间：
2009-09
影响因子：
5.2
通讯作者：
Hui Zhang;Hong Wu;L. Fan;Fei Li;Chunhua Gu;Min Jia
中科院分区：
文献类型：
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作者：
Hui Zhang;Hong Wu;L. Fan;Fei Li;Chunhua Gu;Min Jia
采用优化工艺制备了红霉素(EM)pH敏感型甲基丙烯酸缩水甘油酯衍生葡聚糖(Dex-GMA)/丙烯酸(AAc)纳米粒。不同pH下的粒径分布和药物释放曲线表明，聚(Dex-GMA/AAc)纳米粒具有pH敏感性。在pH为1.2时，纳米粒子的平均直径约为60 nm。而在pH为7.4时，它增加到约250 nm。在pH 1.2条件下，2 h后EM的释放量约为初始载药量的7%。而在pH为7.4时，2 h和6 h的降解率分别为17.8%和30.9%。结果表明，聚(Dex-GMA/AAc)纳米粒在酸性胃内能轻微释放EM，而在碱性肠道中释放较多。所制备的纳米颗粒具有部分可降解性，且具有良好的生物相容性。本研究表明，聚(Dex-GMA/AAC)纳米粒是一种潜在的结肠靶向载体，可以保持EM良好的药物剂型。波兰姆。Compo.，2009。©2008塑料工程师学会
An optimized procedure was used to prepare erythromycin (EM)-loaded pH-sensitive glycidyl methacrylate derivatized dextran (dex-GMA)/acrylic acid (AAc) nanoparticles. The size distribution and drug release profile at different pH demonstrated that poly(dex-GMA/AAc) nanoparticles possessed pH-sensitivity. At pH 1.2, the mean diameter of nanoparticles was about 60 nm. While at pH 7.4 it increased approximately to 250 nm. The release of EM was about 7% of initial loading after 2 h at pH 1.2. However, at pH 7.4 it reached to 17.8%, 30.9% after 2 and 6 h, respectively. The results demonstrated that poly(dex-GMA/AAc) nanoparticles could release EM slightly while passing through acerbic stomach, whereas in the alkaline intestine the drug is released considerably. The prepared nanoparticles were partially degradable and also had satisfactory biocompatibility. This study suggests that the poly(dex-GMA/AAc) nanoparticles are potential colon-specific targeting carriers, which can keep promising pharmaceutical dosage form of EM. POLYM. COMPOS., 2009. © 2008 Society of Plastics Engineers