Trimethyltin-induced changes in gross morphology of the hippocampus.
Trimethyltin-induced changes in gross morphology of the hippocampus.
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三甲基锡诱导海马体总体形态的变化。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
Wonderlin Wf
中科院分区：
文献类型：
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作者：
Dyer Rs;Deshields Tl;Wonderlin Wf
急性暴露于三甲基锡（TMT）引起海马形态学改变。本研究的目的是达到一个简单的方法，定量评估的总体变化的形态，然后可以作为一个相关的TMT毒性研究。成年Long-Evans雄性hooded大鼠接受TMT氯化物单次给药，并在给药后（a）11天内;（B）30天后;或（c）105天后处死。在探索的各种形态学测量中，最简单和最明显的剂量相关性是锥体细胞线的长度，从CA 1到CA 3c。TMT以剂量和时间依赖性方式缩短了这条线。细胞损失似乎开始于CA 3c，并随着给药后剂量和时间的增加而进展至CA 3b和CA 3a。它的结论是，这种测量可以提供一个有用的形态学相关的生理和行为研究TMT毒性。
: Acute exposure to trimethyltin (TMT) produces alterations in hippocampal morphology. The purpose of this study was to arrive at a simple method for quantitative assessment of the gross changes in morphology which could then be used as a correlate in studies of TMT toxicity. Adult Long-Evans male hooded rats were treated with a single dose of TMT chloride and sacrificed either (a) within 11 days; (b) following 30 days; or (c) 105 days following treatment. Among a variety of morphological measures explored, the easiest and most clearly dosage-related was length of the line of pyramidal cells, from CA1 through CA3c. TMT shortened this line in a dosage- and time-dependent manner. Loss of cells appeared to begin in CA3c and progress through CA3b and CA3a as a dosage and time since treatment increased. It was concluded that this measurement may provide a useful morphological correlate for physiological and behavioral studies of TMT toxicity.