Fabrication of porous titanium scaffolds by stack sintering of microporous titanium spheres produced with centrifugal granulation technology
Fabrication of porous titanium scaffolds by stack sintering of microporous titanium spheres produced with centrifugal granulation technology
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DOI：
10.1016/j.msec.2014.07.026
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发表时间：
2014-10-01
影响因子：
7.9
通讯作者：
Zhang, Xingdong
中科院分区：
文献类型：
--
作者：
Chen, Hongjie;Wang, Chunli;Zhang, Xingdong
微孔性在生物材料支架的生物活性和骨诱导性中起着关键作用。本研究开发了一种简单的制备多孔钛支架的新方法，该支架具有均匀的多孔结构，高度可控的孔径和良好的生物相容性。该方法是基于堆叠烧结的微孔钛球生产的离心造粒的商业钛粉。支架的大孔（180.0-341.8 μ m）和微孔（6.1-11.8 μ m）分别取决于钛球和钛粉的尺寸。支架的抗压强度（83.4- 108.9MPa）足以修复承重骨缺损。此外，支架中钛球粗糙凸起的表面上存在丰富的微孔，更有利于血清蛋白的吸附，从而促进间充质干细胞（MSCs）的生长。(C)© 2014 Elsevier B. V.保留所有权利。
Microporosity plays a key role in bioactivity and osteoinductivity of a biomaterial scaffold. A simple new approach to fabricating load-bearing porous titanium (Ti) scaffolds with uniform porous structure, highly controllable pore size and excellent biocompatibility was developed in the present study. This method was based on stack sintering of microporous Ti spheres produced with centrifugal granulation of commercial Ti powders. Macropores (180.0-341.8 mu m) and micropores (6.1-11.8 mu m) of the scaffolds were dependent on the sizes of the Ti spheres and the Ti powders, respectively. The compressive strength of the scaffolds (83.4-108.9 MPa) was high enough for the repair of load-bearing bone defects. Besides, the abundant micropores occurred on the rough and convex surface of the Ti spheres in the scaffolds were more favorable for adsorption of serum proteins, and thus promoted the growth of mesenchymal stem cells (MSCs). (C) 2014 Elsevier B.V. All rights reserved.