Cytoskeleton assembly in Toxoplasma gondii cell division.
Cytoskeleton assembly in Toxoplasma gondii cell division.
复制标题
DOI：
10.1016/b978-0-12-394309-5.00001-8
复制
发表时间：
2012
影响因子：
--
通讯作者：
Gubbels, Marc-Jan
中科院分区：
文献类型：
--
作者：
Anderson-White, Brooke;Beck, Josh R.;Chen, Chun-Ti;Meissner, Markus;Bradley, Peter J.;Gubbels, Marc-Jan
原生动物寄生虫门Apicomplexa的细胞分裂在不同物种之间以及同一寄生虫的不同生命阶段之间显示出惊人的多样性。在大多数情况下，单个寄生虫感染宿主细胞会形成多倍体细胞，单个子代在依赖于最后一轮有丝分裂的过程中发芽。与其他顶端复合体不同，弓形虫通过内部萌发组成的二元过程进行分裂，每轮分裂只产生两个子细胞。由于弓形虫在实验上是可接近的，并且表现出最简单的分裂模式，它已经表现为一个顶端复合体形成的模型。在这里，我们回顾了关于皮质细胞骨架支架的组装在子寄生虫形成过程中所起的突出作用的新的见解。
Cell division across members of the protozoan parasite phylum Apicomplexa displays a surprising diversity between different species as well as between different life stages of the same parasite. In most cases, infection of a host cell by a single parasite results in the formation of a polyploid cell from which individual daughters bud in a process dependent on a final round of mitosis. Unlike other apicomplexans, Toxoplasma gondii divides by a binary process consisting of internal budding that results in only two daughter cells per round of division. Since T. gondii is experimentally accessible and displays the simplest division mode, it has manifested itself as a model for apicomplexan daughter formation. Here we review newly emerging insights in the prominent role that assembly of the cortical cytoskeletal scaffold plays in the process of daughter parasite formation.