Placental transfer of arsenic to fetus of Dall's porpoises (Phocoenoides dalli)
Placental transfer of arsenic to fetus of Dall's porpoises (Phocoenoides dalli)
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DOI：
10.1016/j.marpolbul.2005.01.011
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Miyazaki, N
中科院分区：
文献类型：
--
作者：
Kubota, R;Kunito, T;Miyazaki, N
为了研究鲸目动物胎盘中砷向胎儿的转移，对2000年在日本三陆海域采集的达尔氏江豚母体和胎儿的肝脏、肌肉、肾脏和鲸脂中总砷和各砷化合物的含量进行了测定。在多尔江豚的所有组织中都检测到了砷。母鼠肝、肾、肌肉和脂肪中总砷含量分别为0.76、0.69、0.35和0.55微克/克湿重，胎儿分别为0.28、0.23、0.26和0.07微克/克湿重。在所有组织中，母江豚的总砷浓度均高于胎儿。砷形态分析表明，砷甜菜碱是母体和胎儿肝脏、肾脏和肌肉中的主要砷化合物。组织中砷甜菜碱占总砷的百分比为76.0%~91.0%。在母体和胎儿的组织中也检测到了二甲基砷酸、砷胆碱、甲基砷酸和一种未知的砷化合物，而在胎儿的组织中未检测到四甲基砷离子。这些结果表明，在多尔江豚体内，砷甜菜碱、二甲基砷酸、砷胆碱和甲基砷酸是可以从母体转移到胎儿的。据我们所知，这是关于海洋哺乳动物胎盘中砷化合物向胎儿转移的首次报道。(C)2005爱思唯尔有限公司。保留所有权利。
Concentrations of total arsenic and individual arsenic compounds were determined in liver, muscle, kidney and blubber of mother and fetus of Dall's porpoises collected from off Sanriku, Japan, in the year 2000 to characterize the placental transfer of arsenic to fetus in cetaceans. Arsenic was detected in all the tissues of Dall's porpoises. Total arsenic concentrations in liver, kidney, muscle and blubber were 0.76, 0.69, 0.35 and 0.55 mu g/g wet wt, respectively, for mother and 0.28, 0.23, 0.26 and 0.07 mu g/g wet wt, respectively, for fetus. In all the tissues, concentrations of total arsenic in mother Dall's porpoise were higher than in fetus. Arsenic speciation revealed that arsenobetaine was the major arsenic compound in liver, kidney and muscle of both mother and fetus. The percentage of arsenobetaine to total arsenic ranged from 76.0 to 91.0% in the tissues. Dimethylarsinic acid, arsenocholine, methylarsonic acid and an unidentified arsenic compound were also detected in tissues of both mother and fetus as minor constituents, whereas tetramethylarsonium ion was not detected in tissues of the fetus. These results suggest that arsenobetaine, dimethylarsinic acid, arsenocholine and methylarsonic acid are transferable from mother to fetus in Dall's porpoises. To our knowledge, this is the first report on placental transfer of arsenic compounds to fetus in marine mammals. (c) 2005 Elsevier Ltd. All rights reserved.