Early diffusion weighted magnetic resonance imaging can predict survival in women with locally advanced cancer of the cervix treated with combined chemo-radiation
Early diffusion weighted magnetic resonance imaging can predict survival in women with locally advanced cancer of the cervix treated with combined chemo-radiation
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DOI：
10.1007/s00330-012-2496-0
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发表时间：
2012-11-01
影响因子：
5.9
通讯作者：
Parkin, David
中科院分区：
文献类型：
--
作者：
Somoye, Gbolahan;Harry, Vanessa;Parkin, David
目的：探讨扩散加权成像（DWI）对晚期宫颈癌同步放化疗患者生存的预测价值。招募了20名接受晚期宫颈癌治疗的妇女，随访时间中位数为26个月（范围< 1至43）。他们在治疗前、治疗开始后2周（治疗中期）和治疗结束时分别进行了DWI检查。根据感兴趣区域（ROI）计算表观扩散系数（ADC）。对所有参与者进行随访资料回顾。将ADC值与死亡率进行比较（Mann-Whitney检验）。评估进展时间和总生存期（Kaplan-Meier生存图）。有14名幸存者。存活组治疗中期ADC中位数高于非存活组，分别为1.55和1.36 (x10(-3)/mm(2)/s), P = 0.02。治疗开始后14天，存活组ADC的中位变化显著高于非存活组，分别为0.28和0.14 (x10(-3)/mm(2)/s), P = 0.02。没有证据表明幸存者和非幸存者在预处理基线或治疗后ADC值之间存在差异。早期治疗晚期宫颈癌的功能性DWI可能为预测生存提供有用的信息。弥散加权磁共振成像（DWI）在宫颈癌中的应用越来越广泛。早期治疗宫颈癌的功能性DWI可能有助于预测生存率。DWI可以帮助临床医生适当地定制或个性化治疗。这可能会限制无效治疗的毒性，并允许早期替代治疗。
To assess the predictive value of diffusion weighted imaging (DWI) for survival in women treated for advanced cancer of the cervix with concurrent chemo-radiotherapy.Twenty women treated for advanced cancer of the cervix were recruited and followed up for a median of 26 (range < 1 to 43) months. They each had DWI performed before treatment, 2 weeks after beginning therapy (midtreatment) and at the end of treatment. Apparent diffusion coefficient (ADC) values were calculated from regions of interest (ROI). All participants were reviewed for follow-up data. ADC values were compared with mortality status (Mann-Whitney test). Time to progression and overall survival were assessed (Kaplan-Meier survival graphs).There were 14 survivors. The median midtreatment ADC was statistically significantly higher in those alive compared to the non-survivors, 1.55 and 1.36 (x10(-3)/mm(2)/s), respectively, P = 0.02. The median change in ADC 14 days after treatment commencement was significantly higher in the alive group compared to non-survivors, 0.28 and 0.14 (x10(-3)/mm(2)/s), respectively, P = 0.02. There was no evidence of a difference between survivors and non-survivors for pretreatment baseline or post-therapy ADC values.Functional DWI early in the treatment of advanced cancer of the cervix may provide useful information in predicting survival.aEuro cent Diffusion weighted magnetic resonance imaging (DWI) is increasingly used in cervical cancer.aEuro cent Functional DWI early in treatment of cervical cancer may help predict survival.aEuro cent DWI may help clinicians to tailor or individualise treatment appropriately.aEuro cent This may limit toxicity from ineffective treatment and allow early alternative therapy.